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|本期目录/Table of Contents|

氧自由基的长生与冠心病伴有心衰之间关系的研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1991年第2期
页码:
55-59,64
栏目:
论著
出版日期:
1991-03-01

文章信息/Info

Title:
Studies on the Relationship between Production of Oxygen Free Radicals and Cardiac Failure of Coronary Artery Disease
作者:
-
Author(s):
Chen Lihua1; Zang Yimin1; Bai Buyun3;  Zhu Miaozhang1; Zhao Baolu2;  Hou Jingwu2;  Xin Wenjuan2
1.Department of Physiology,Fourth Military Medical University,Xi'an;2.Institute of Biophysics, Academia Sinica, Beijing;3.Department of Cardiovascular Disease, 514 hospital,Beijing
关键词:
-
Keywords:
free radicals; Oxygen; Superoxide dismutase; Malondialdehyde; Heart failure;  congestive
分类号:
-
DOI:
-
文献标识码:
-
摘要:
-
Abstract:
ABSTRACT:In this paper, the relationship between Oxygen Free Radicals(OFR)and cardiac failure of Coronary Artery Disease(CAD) was studied.The authors analyse the release of OFR,as measured by Lumin-dependent chemiluminescence, from the polymorphonuclear leukocytes(PMN); the activity of plasma superoxide dismutase(SOD)and the concentration of malondialdehyde(MDA)in patients of CAD with heart failure. The results showed that compared with the health controls and the group of CAD without heart failure, the re'ease of OFR in respiratory burst of the PMN stimulated with PMA(phorbol myristate acetate)and the concentration of MDA in plasma were significantly increased (p<0.05) and the activity of SOD was markedly Iower(p<0.05)in the group of CAD with heart failure. It suggests that the enhanced production of OFR by PMN, the increased concen tration MDA in plasma and the decreased SOD might be associated with the genesis and development of cardiac failure. The use of agents that reduce the amount of OFR would be of value in the prevention and treatment of cardiac failure.

参考文献/References

[1]Hess ML, et al. J Mo Cell Cardiol 1981;13:767.

[2]The Criteria Committee of the New York Heart Association. Diseases of the heart and blood vessels. Nomenclature and Criteria for Diagnosis, Boston,Little Borwn, 1964.

[3]Market M, et al. Methods in Enzymology Vol. 105. Packer L, ed. Orlando:Academic Press,1984:358.

[4]Shult PA, et al. J Lab Clin Med 1985;106:638.

[5]Bird RP, et al. Methods in Enzymology Vo1.105.New York:Academic Press,1984:299.

[6]Bensiger R O, et al. Analytic Biochemistry 1981;116:142.

[7]Fantone J C, eL al.Am J Pathol 1982;107:397.

[8]Prasad K, et al. Angio'ogy 1989; May 472.

[9]Prasad K, et al. Am Heart J 1989;June 1196.

[10]Mccord J M Free Radical Biology and Medicine1988;4:9.

备注/Memo

备注/Memo:
收稿1990年12月
更新日期/Last Update: 1991-03-01