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|本期目录/Table of Contents|

一个新的实验性冠状动脉痉挛动物模型(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1994年第4期
页码:
205-208
栏目:
论著
出版日期:
1994-10-01

文章信息/Info

Title:
A study of a new animal，model of experimental coronary artery spasm
作者:
郭衡山1 邓鹤秋1 刘兰平2 冯常森1 吴宏超1 刘 泽1 聂道海1
第一军医大学珠江医院 1心内科 2检验科 广州 510282
Author(s):
Guo Hengshan1; Deng Heqiu1; Liu Lanping2; Feng Changsen1; Wu Hongchao1; Liu Ze1 and Nie Daohai1
Department of Cardiology，Zhujiang Hospital，First Military Medical University，Guangzhou 510282
关键词:
冠状动脉痉挛; 实验性; 动物模型; 脑垂体后叶素
Keywords:
coronary artery spasm; experimental; animal model; injectio pitritarii posterisris
分类号:
-
DOI:
-
文献标识码:
-
摘要:
本研究探索一个实验性冠状动脉痉挛(CAS)动物模型。健康犬12只，分三组，静脉麻醉开胸分离左冠脉前降支。Ⅰ组（5只）：冠脉滴敷脑垂体后叶注射液(IPP)诱发CAS：Ⅱ组(5只）：先形成冠脉部分狭窄再加上诱发CAS，对照组(2只)：冠脉滴敷生理盐水。CAS的判断及结果Ⅰ、Ⅱ组施药后冠脉血流量(CBF)明显减少(阳性例数5／5)，心电图呈缺血性改变（阳性例数4／5)及严重室性心律紊乱，第Ⅱ组改变更显著。对照组的CBF及心电图无改变。本实验诱发CAS方法易行。成功率高，重复性好。其优点是诱发CAS的部位可以选择，作用时间相对可控;血管收缩剂不直接进入血液循环．对冠脉以外其它血管动力学无影响，也控制了血液内各种因子检测的准确性。本实验模型可以用于进行CAS的病理生理、生化、病理形态和治疗学的研究。
Abstract:
A new animal model of experimental coronary artery spasm(CSA)was established in dogs．A main branch of lef anterior descending coronary artery(LAD)was dissected under open-chest operation in intravenously anaesthetized dogs．Twelve healthy dogs were divided into three groups．In group A(5 dogs),CAS was induced by dripping a few drops of injectio pituitarii posterioris(IPP)on a slip of gauze,in which the dissected LAD was wrapped．In group B(5 dogs)，CAS was induced in the same way as in group A following a partial stenosis of LAD．In group C(2 dogs),a few drops of normal saline were given instead of IPP.Coronary blood flow(CBF)was decreased markedlyin all dogs of groups A and B after IPP Was given as a vasoconstrictor．Electrocardiogram revealed changes of myocardial．ischemia and severe ventricular arrhythmia in 8 dogs of groups A and B；and these changes were more significant in group B than in group A．However，no such changes of CBF and ECG were observed in the control group．These results showed that the animal model of experimental coronary artery spasm could be used in pathological，physiological and therapeutical study of CAS because of its following advantages：①It is convenient and highly reproducible．②It is highly selective in the location of CAS and the duration of CAS can be controlled．③It enables assessment of the direct effect of vasoconstrictor on the canine coronary circulation without secon．dary ffects resulting from changes in other hemodynamic variables which might be associated with systemic circulation．

参考文献/References

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［2］陈士良，臧益民，朱妙章，等．冠状动脉狭窄对血流量的影响．生理学报1989；41：9l.

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［4］James A,Robert MB,Matthew AL,el a1.Responses of dog large coronary arteries to contrictor and dilator substance for the cause and treatment of variant angina pectoris．Am J Cardiol 1983;52:52A.

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［6］江一清，施华强，那 顺，等．实验性冠状动脉痉挛动物模型血液动力学、心电图、冠脉造影、生化和病理研究．中华心血管病杂志，1986；l4：169.

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备注/Memo

备注/Memo:
Received 1993-06-26；revised 1993-12-21
更新日期/Last Update: 1994-10-01