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急性缺氧对左心室舒张功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1997年第2期
页码:
78-80
栏目:
论著
出版日期:
1997-03-01

文章信息/Info

Title:
Effect of acute anoxia on diastolic function in left ventricle
作者:
孙　尧X 　陈永红　李万镇
北京医科大学第一医院儿科　北京 100034
Author(s):
Sun Yao1;  Chen Yonghong2;  Li Wanzhen2
1Department of Medicine, Affiliated Hospital, North China Coal Medical College, Tangshan 063000 　2Department of Pediatrics, First Hospital, Beijing Medical University, Beijing 100034
关键词:
乏氧性缺氧　舒张功能;  左室　血气分析
Keywords:
hypoxic anoxia　diastolc function;  left　blood gas analysis　rabbits
分类号:
-
DOI:
-
文献标识码:
-
摘要:
作者取健康家兔17只, 分为两组, 分别吸入氧体积分数为5% (缺氧Ⅰ 组) 和10% (缺氧Ⅱ组)的氮氧混合气, 建立了急性缺氧动物模型, 用有创性心导管方法测定心室舒张功能, 研究缺氧对心室舒张功能的影响。结果显示, é 组和ê 组的心室舒张功能指标分别于缺氧40 min 和50 min 时, 比对照组显著下降;同时收缩功能也下降。本文结果表明, 无论是吸入体积分数较低(5%) 的氧或吸入体积分数相对较高(10% )的氧, 随着缺氧时间的延长, 心室舒张功能都下降。另外, 缺氧所致心室舒张功能障碍时还伴有收缩功能异常。
Abstract:
In recent years ventricular diastolic function has attracted increasing attention. The present study has made an an imalmodel of acute anoxia to investigate the effect of acute anoxia on diastolic function. The rabbits (n=17), separated into two groups, were ventilated with 5% oxygen (Group Ⅰ) and 10% oxygen (Group Ⅱ ). The results showed that the data of diastolic function were decreased significantly as compared to control (P < 0.05) in 40 min and 50 min. At the same time, the systolic function was also decreased significantly. The results suggested that animals ventilated both with 5% oxygen and with 10% oxygen might suffer from diastolic dysfunction in left ventricle if the anoxia was kept long enough, abnormal systolic function accompanied diastolic dysfunction.

参考文献/References

［1］陈永红, 李万镇.超声心动图对婴幼儿肺炎左右心室舒张功能的研究.中华儿科杂志, 1992;30: 261.

［2］Maruyama J , Tobise K, Kawashima E. The effect of acute hypoxia on left ventricular function with special reference to diastolic function. Jpn Circ J , 1992; 56: 998.

［3］Dougherty AH, Naccarelli GV , Grag EL , et al.Congestive heart failure with normal systolic function. Am J Cardiol, 1984; 54 (7) : 778.

［4］Packer M. Abnormalities of diastolic function as a potential cause of exercise intolerance in chronic heart failure. Circulation, 1990; 81(Suppl Ⅲ ) : Ⅲ- 278.

备注/Memo

备注/Memo:
Received 1996-03-29　revised 1996-12-25 X研究生，现在华北煤炭医学院附属医院内一科 唐山 063000
更新日期/Last Update: 1997-03-01