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血管利钠肽对大鼠肺动脉的舒张作用及机理sup>ⅹ(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1998年第2期
页码:
69-71
栏目:
论著
出版日期:
1998-03-01

文章信息/Info

Title:
Vasorelaxing effect of vasonatrin peptide on pulmonary artery in rats
作者:
冯华松1　臧益民1　朱妙章1　裴建明1　王跃民1　牛国保1　王　琳2　施溥涛3
1第四军医大学生理学教研室　西安710032　1第四军医大学唐都医院呼吸内科　1上海生物化学研究所
Author(s):
Feng Huasong1;  Zang Yimin1;  Zhu Miaozhang1;  Pei Jianming1;  Wang Yuemin1;  Niu Guobao1; Wang Lin2;  Shi Putao3
1Department of physiology, Fourth Military Medical University, Xi′an 710032　2Department of Respiratory Disease, Tongdu Hospital,Fourth Military Medical University　3Biochemistry Institute of Shanghai
关键词:
血管利钠肽　肺动脉　主动脉　大鼠
Keywords:
vasonatrin peptide　　pulmonary artery　　aorta　　rats
分类号:
-
DOI:
-
文献标识码:
-
摘要:
血管利钠肽(VNP) 是新近人工合成的由27个氨基酸残基组成的肽类物质, 它是心房利钠利尿肽(ANP)和C 型利钠利尿肽(CNP) 的杂交物。我们采用离体血管灌流的方法观察了VNP对离体大鼠肺动脉和腹主动脉的舒张作用。表明VNP对内皮完整的与去内皮的肺动脉和腹主动脉均有浓度依赖性舒张作用, 其对抗去甲肾上腺素(10 μmo l/L ) 或KCl(60 mmol/L) 收缩肺动脉的最大舒张效应明显大于腹主动脉; 内皮完整和去内皮组之间无显著性差异; 在浴槽内预先加入优降糖可显著减低肺动脉和腹主动脉对VNP的舒血管效应, 预先加入心得安则不明显影响VNP对肺动脉和腹主动脉的舒血管作用。提示VNP对上述血管的舒张作用不依赖于内皮的存在, 但受ATP敏感性钾通道的调控。
Abstract:
Vasonatrin peptide (VNP) is a newly synthesized 27-amino acid peptide, which is a chimera of atrial natriuretic peptide(ANP) and C-type natriuretic peptide(CNP).In the present study, the vasorelaxing effect of VNP on rat pulmonary artery was investigated by in vitro perfusion, in contrast to the abdominal aorta. The results showed that VNP caused concentration-de-pendent relaxations in isolated rat pulmonary artery and abdominal aorta with and without endothelium. The maximal relaxation of VNP to reverse 60 mmol/L KCl or 10 umol/L norepinephrine-induced contraction was significantly greater in pulmonary artery than in abdominal aorta. The vasodilating actions induced by VNP, were significantly attenuated in organ chambers of pre-incubation with glybenzcy clamide, and not changed in organ chambers of pre-incubation with propranolol. These results suggest that the diastolic effect of VNP on the above mentioned blood vessels is independent on endothelium and is also modulated by blockers of ATP-sensitive K+ channels.

参考文献/References

［1］Wei CM , Kim CH, Miller VM , et al. Vasonatrin peptide: A unique synthetic natriuretic and vasorelaxing peptide. J Clin Invest, 1993; 92: 2048.

［2］Wei CM , Kim CH, Khraibi AA , et al. Atrialnatriuretic peptide and C-type natriuretic peptide in spontaneously hypertensive rats and their vasorelaxing actions in vitro.Hypertension, 1994; 23 (Part 2) : 903.

［3］Suga S, Nakao K, Kishimoto I, et al. Phenotype-related alteration in exp ression of natriuretic peptide receptor in aortic smooth muscle cells. Circ Res, 1992; 71: 34.

［4］Bradydne JE, Quayle JM , Standen NB, et al. Role of potassium channels in the vascular response to endogenous and pharmacological vasodilators. Blood Vessels,1991; 28: 147.

［5］Quast U , Cook NS. In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim , and their inhibition by glibenclamide. J Pharmacol Exp Ther, 1989; 250: 261.

［6］Nally JE, Docherty CC, Clayton RA , et al. Bronchodilator and pre-protective effects of urodilatin in bovine bronchi in vitro: Comparison with atrial natriuretic peptide. Br J Pharmacol, 1995; 114 (7) : 1391.

备注/Memo

备注/Memo:
(收稿1997-10-05)国家自然科学基金资助项目No.39770317
更新日期/Last Update: 1998-03-01