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|本期目录/Table of Contents|

皮质醇对牛蛙心肌收缩的快速作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1999年第2期
页码:
100-101,105
栏目:
论著
出版日期:
1999-03-01

文章信息/Info

Title:
Rapid effect of cortisol on myocardial contractility in bullfrog
作者:
郝怡鑫X 　王建文　邢宝仁
第二军医大学生理学教研室 上海 200433
Author(s):
Hao Yixin; Wang Jianwen;  Xing Baoren
Department of physiology, Second Millitary Medical University, Shanghai 200433
关键词:
皮质醇　心肌收缩　蛙;  牛
Keywords:
cortisol 　myocardial contraction　rana;  catesbeiana
分类号:
-
DOI:
-
文献标识码:
-
摘要:
本实验采用八木氏法灌流牛蛙心脏, 经换能器、放大器输入计算机记录心肌的收缩活动, 观察皮质醇对牛蛙心肌收缩的作用。结果如下: ①灌流1×10-6mol/L皮质醇, 蛙心收缩幅度增大, 潜伏期平均为18.7 s, 蛙心收缩频率无明显改变(n=60)。②灌流2×10-7mol/L～1×10-6mol/L 不同浓度皮质醇后, 随着皮质醇浓度的增加, 心肌收缩幅度也增大, 表现明显的量效关系(n=20)。③甾体激素胞内受体阻断剂—1×10-6mol/LRU38486不能阻断皮质醇的作用(n=20)。④经蛋白合成抑制剂—放线菌酮作用20 min后, 再灌流1×10-6mol/L 皮质醇, 心肌收缩幅度仍增大(n= 20)。上述结果提示: 皮质醇对牛蛙心肌收缩具有快速增强作用。
Abstract:
The effect of cortisol on myocardial contractility in bullfrog were studied with the BAMU -HARTUNG′S method.The results are as follows: ①The magnitude of myocardial contractility was increased when the heart of bullforg was perfused with 1×10-6mol/L cortisol, the latency was 18.7±2.3 second (n=60).② In the concentration range of 2×10-7mol/L to 1×10-6mol/L of cortisol, the effect of cortisol was concentration dependent.③The perfusion of 1×10-6mol/L RU38486 has no significant influence on the responsce of myocardial contratility to 1×10-6mol/L cortisol(n=20). ④1The potentation of myocardial contractility by 1×10-6mol/L cortisol did not diminished when the preparation was preincubated in the presence of actidione for twenty minutes (n=20).This results indicate that the cortisol has the rapid excitatory effect on the myocardial contractility of bullfrog.

参考文献/References

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备注/Memo

备注/Memo:
(收稿1998-04-15　修回1998-10-21)ⅹ现在军医二大队九四队
更新日期/Last Update: 1999-03-01