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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

1999年第3期

页码:

152-153,156

栏目:

论著

出版日期:

1999-05-01

文章信息/Info

Title:

Evaluation of left ven ricular function in uremic myocardiopathy using 99mTc-MIBI myocardial imaging

作者:

侯英萍¹　乔宏庆¹　刘水琴²　马兴荣¹

第四军医大学西京医院　1核医学科　2肾脏内科　西安 710032

Author(s):

Hou Yingping1;  Qiao Hongqing1;  Liu Shuiqin2;  Ma Xingrong1

Department of Nuclear Medicine, Xijing Hospital, Xi′an 710032

关键词:

尿毒症　心功能　放射性核素显像　^99mTc-MIBI

Keywords:

uremia　heart function　radionuclide imaging　^99mTc-MIBI

分类号:

-

DOI:

-

文献标识码:

-

摘要:

本研究应用^99m锝-甲氧基异丁基异腈(^99mTc-MIBI)心肌显像,计算左心腔/心肌计数比值(CMR)和肺/心计数比值(LHR),从而评价尿毒症心肌病左心功能。选择30例正常对照组和28例有明确的尿毒症病史伴左心室扩大、充血性心力衰竭而确诊为尿毒症心肌病患者(尿毒症组),行静息^99mTc-MIBI心肌血流灌注显像, 计算并比较对照组和尿毒症组以及尿毒症两个亚组的CMR和LHR。结果显示, 尿毒症组LHR(0.33±0.05) 高于对照组(0.29±0.04),P<0.01, 而CMR(0.20±0.12)也明显低于对照组(0.42±0.09),P<0.01; 病程大于5年尿毒症亚组(0.15±0.11)CMR低于病程小于和?或等于5年亚组(0.25±0.12) , P<0.05, 但LHR在两亚组间无差异。作者认为由^99mTc-MIBI心肌显像方法所获得的CMR和LHR 两项定量指标能够反映尿毒症心肌病患者左心功能障碍状况, 有助于临床治疗和预后估计。

Abstract:

The left ventricular function of uremic myocardiopathy was evaluated by using left ventricular cavity-to-myocardial count ratio(CMR) and lung-to-heart uptake ratio (LHR)with ^99mTc-MIBI myocardial imaging. Rest ^99mTc-MIBI myocardial perfusion imaging was performed in 28 patients with uremic myocardiopathy and 30 normal controls. Clinically those patients were found suffering from ventricular enlargement and congestive heart failure. According to the course of disease the patients were divided into two subgroups: subgroup 1 with the disease course of less than or equal to 5 years (13 cases) , and the disease course of subgroup 2 was longer than 5 years(15 cases). CMR and LHR were calculated and compared. LHR in the group of patients (0.33±0.05) was higher than that of the controls (0.29±0.04) , P<0.01. CMR in the group of patients (0.20±0.12) was significantly lower than that of the controls (0.42±0.09) , P <0.01.CMR of subgroup 2(0.15±0.11) was lower than that of subgroup 1 (0.25±0.12). No difference was found in LHR between the two subgroups. CMR and LHR, measured by^99mTc-MIBI imaging, could predict left ventricular dysfunction in patients with uremic myocardiopathy.

参考文献/References

［1］屈婉莹, 鲁振萍, 周　颖, 等. 99m Tc-MIBI心肌断层显像肺摄取的定量分析. 中华核医学杂志, 1996; 16 (4) : 217.

［2］ Roberti R, Van Tosh A , Baruchin M , et al. Left ventricular cavity-to-myocardial count ratio: a new parameter for detecting resting left ventricular dysfunction directly from tomographic thallium perfusion scintigraphy. J Nucl Med , 1993; 34 (2) : 193.

［3］Giubbini R, Campini R, Milan E, et al. Evaluation of Technetium-99m-sestamibi lung uptake: correlation with left ventricular function. J Nucl Med, 1995; 36 (1) : 58.

［4］周 颖, 屈婉莹, 米 明, 等. 左室腔与心肌计数比值作为左心室功能参数的初步探讨. 中华核医学杂志, 1995; 15 (4) : 217.

［5］Bingham JB, Mckusick KA , Strauss HW , et al. Influence of coronary artery disease on pulmonary uptake of Thallium-201.Am J Cardiol, 1980; 46 (5) : 821.

［6］Gibson RS, Watson DD, Carabello BA , et al. Clinical implications of increased lung uptake of Thallium-201 during exercise scintigraphy 2 weeks after myocardial infarction. Am J Cardiol, 1982, 49 (7) : 1586.

备注/Memo

备注/Memo:

(收稿1998-12-10　修回1999-03-04)

常用功能

更新日期/Last Update: 1999-05-01