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一氧化氮在心肌缺血再灌注时对心肌功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1999年第3期
页码:
194-196
栏目:
综述
出版日期:
1999-05-01

文章信息/Info

Title:
-
作者:
丁 钢1　左春梅2　黄永麟3
解放军211医院　1心内科　2妇产科　哈尔滨市 150080　3哈尔滨医科大学第一附属医院心血管研究所
Author(s):
-
关键词:
一氧化氮　心肌再灌注　心功能
Keywords:
-
分类号:
-
DOI:
-
文献标识码:
-
摘要:
动物实验发现心肌缺血/再灌注损伤能降低心肌细胞Ca2+依赖的一氧化氮合酶的活性,导致内皮细胞和心肌细胞功能障碍, 使细胞合成一氧化氮的能力受损。心肌缺血所导致的心功能障碍与心肌组织内一氧化氮含量减少有关, 缺血后再灌注一氧化氮合成前体左旋精氨酸, 可改善因缺血引起的左室舒缩功能障碍,而一氧化氮合酶抑制剂可对心功能产生负性肌力效应, 影响缺血后心功能的恢复。
Abstract:
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参考文献/References

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备注/Memo

备注/Memo:
(收稿1998-07-15)
更新日期/Last Update: 1999-05-01