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|本期目录/Table of Contents|

降钙素基因相关肽对顿抑心肌心功能的影响x(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1999年第4期
页码:
220-221,224
栏目:
论著
出版日期:
1999-07-01

文章信息/Info

Title:
Effects of calcitonin gene-related peptide on the cardiac function of stunned myocardium
作者:
吴宏超1　钱学贤1　李立平2
第一军医大学珠江医院　1心内科　2消化科, 广州 510282
Author(s):
Wu Hongchao1; Qian Xuexian1; Li Liping2
1Department of Cardiology, 2Department of Gastroenterology, 2Zhujiang Hospital, First Military Medical University, Guangzhou 510282
关键词:
心肌顿抑　基因相关肽; 降钙素　心功能
Keywords:
myocardial stunning　gene-related peptide;  calcitonin　cardiac function
分类号:
-
DOI:
-
文献标识码:
-
摘要:
建立大鼠心肌顿抑模型, 观察降钙素基因相关肽(CGRP)对顿抑心肌心功能的影响。发现再灌注前给予CGRP,可显著减轻心肌顿抑的程度,加快缺血后心功能障碍的恢复。说明CGRP可部分预防心肌顿抑的发生。
Abstract:
The effects of calcitonin gene-related peptide(CGRP)on the cardiac function of stunned myocardium was studied in an in vivo ratmodel with myocardial stunning. The results suggested that CGRP given intravenously just before reperfusion could significantly lessen myocardial stunning,making a rapid recovery of the postischemic dysfunction. Therefore CGRP could partly prevent the development of myocardial stunning.

参考文献/References

［1］Braunwald E, Kloner RA. The stunned myocardium: prolonged,post ischemic ventricular dysfunction. Circulation, 1982; 66 (6) :1146.

［2］Samy RN , Silvesty SC, Zane Atkins, et al. Calcitonin gene-related peptide improves recovery from reversible myocardial ischemia. J Am Coll Cardiol, 1995; Special issue (0735-1097):43A.

［3］陈金明, 龚肖奇, 陈思聪, 等. 大鼠可逆性心肌缺血后功能障碍致心肌顿抑的模型中国病理生理杂志, 1996; 12 (2) : 223.

［4］Bolli R. Myocardial“Stunning ”in men. Circulation, 1992; 86 (6) :1671.

［5］Pierard LA ,De lanesheere CM ,Berthe C, et al. Identification of viable myocardium by echocardiography during dobutamine infusion in patients with myocardial infarction after thrombolytic therapy:comparison with positron emission tomography. J Am Coll Cardiol, 1990; 15 (5) : 1021.

［6］Smart S, Sawada S, Ruan T, et al. Dobutam ine echocardiography predicts recovery after thrombolysis in myocardial infarction. (abstract) Circulation, 1990; 82 (suppl Ⅲ ):Ⅲ-274.

[7]李兆萍, 范新民, 唐朝枢, 等.降钙素基因相关肽对缺血心肌细胞的保护作用.北京医科大学, 1988; 20 (5) : 326.

[8]裴建明, 牛国保, 朱妙章, 等.降钙素基因相关肽对缺血及再灌注心肌的保护作用.第四军医大学学报, 1995; 16 (4) : 262.

[9]于 严, 董林旺, 姚兴海, 等.降钙素基因相关肽(CGRP)对实验性心肌梗塞的影响.中国病理生理杂志, 1993; 9 (2) : 137.

[10]Zhang JF,Liu J ,Liu XZ, et al. The effect of calcitonin gene-related peptide on arrhythmia caused by adenosine diphosphate and desocetyl-digilanide-C. Int J Cardiol, 1991; 33 (1) : 43.

[11]Zhang JF, Liu J. Stabilization of cardiac rhythm in subsequently fatal ventricular tachycardia and fibrillation by calcitonin gene-related peptide. Int J Cardiol, 1992; 34 (1) : 101.

备注/Memo

备注/Memo:
(收稿1998-09-18　修回1999-01-04)军队九五科研基金资助项目
更新日期/Last Update: 1999-07-01