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降钙素基因相关肽与心律失常(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1999年第4期
页码:
250-251
栏目:
综述
出版日期:
1999-07-01

文章信息/Info

Title:
-
作者:
商立军1　臧益民1　王四旺2　臧伟进3
第四军医大学　1生理学教研室　2药物研究所,西安 710032; 　3西安医科大学心血管生理药理研究室
Author(s):
-
关键词:
降钙素基因相关肽　心律失常　离子通道
Keywords:
-
分类号:
-
DOI:
-
文献标识码:
-
摘要:
降钙素基因相关肽(CGRP)是一种内源性生物活性多肽,对心血管系统的活动具有十分重要的调节作用, 本文作者讨论CGRP与心律失常的关系,抗心律失常作用的可能离子机制.
Abstract:
-

参考文献/References

［1］Rosenfeld MG, Mermod JJ , Amara SG, et al. Production of a novel neuropeptide encoded by the calcitonin gene via tissue specific RNA processing. Nature, 1983; 304: 129.

［2］Zhang JF, Liu J , Liu XZ, et al. Stabilization of cardiac rhythm in subsequently fatal ventricular tachycardia and fibrilliation by calcitonin gene-related peptide. Int J Cardiol, 1992; 34 (2) : 101.

［3］Zhang JF, Liu J , Liu XZ, et al. The effect of calcitonin gene-related peptide on ischemic reperfusion induced arrhythmias in rats. Int J Cardiol, 1994; 46 (1) : 33.

［4］李红梅, 裴建明, 朱妙章, 等. 降钙素基因相关肽的抗室颤作用.心功能杂志, 1997; 9 (1) : 5.

［5］裴建明, 臧益民, 朱妙章, 等. 降钙素基因相关肽抗垂体后叶素引起心肌缺血性电生理改变的观察. 心脏起搏与电生理杂志,1995; 9 (1) : 91.

［6］袁文俊, 孙庆文, 许金廉. 降钙素基因相关肽拮抗内皮素的致心律失常作用. 中国应用生理学杂志, 1997; 13 (1) : 40.

[7] 张万江, 赵志炜, 王　蓉, 等. 降钙素基因相关肽对乌头碱、哇巴因诱发大鼠心律失常的治疗作用. 首都医科大学学报, 1994; 15(2) : 204.

[8]裴建明, 臧益民, 牛国保, 等. 降钙素基因相关肽的心脏电生理作用. 中国应用生理学杂志1996; 12 (1):41.

[9] Ohmura T, Nishio M , kigoshi S, et al. Electrophysiological and mechanical effects of calcitonin gene related peptide on guinea-pig atria. Br J Pharmacol, 1990; 100 (1) : 27.

[10] Ono K, Giles WR. Electrophysiolgical effeets of CGRP in bullfrog and guinea-pig trial myocytes. J Physiol, 1991; 436: 195.

[11]Ono K, Delay M , Nakajima T, et al. CGRP regulates calcium current in heart muscle. Nature, 1989; 340: 721.

[12]Satoh M , Oku R, Maeda A , et al. Possible mechanisms of positive inotropic action of synthetic human CGRP in isolated rat atrium. Peptides, 1986; 7: 631.

[13]Nakajjma T, Takikaw AR, Sugimoto T, et al. Effects of CGRP on membrane currents in mamalian cardiac myocytes. Eur J Physiol, 1991 ; 419 (6) : 644.

[14]陈 新, 孙瑞龙, 王方正, 主编. 临床心电生理学和心脏起搏.人民卫生出版社, 1997:.

[15]Harrey RD, Hume JR. Autonomic regulation of delayed rectifer k+current in mammalian heart involves G p roteins. Am J Physiol, 1989; 257 (3) : H818.

[16]Ishikawa T, Okamura N , Saito A , et al. Positive inotropic effect of calatonin gene related peptide mediated by cyclic AMP in guineapig heart. Circ Res, 1988: 63 (4) : 726.

[17]Jeffery K, Smallwood IA , Schetm A , et al. Effect of activation of ATP dependent K+channel on infarct size in a canine model of ischemia reperfusion injury. J Cardiovasc pharmacol, 1993; 22 (5) : 731.

[18]Quayle JM , Bonev AD, Brayden JE, et al. Calcitonin gene related peptide activated ATP sensitive K+currents in rabbit arterial smooth muscle via Protein kinase A. J Physiol, 1994; 475 (1) : 9.

备注/Memo

备注/Memo:
(收稿1999-06-06　修回1999-06-09)
更新日期/Last Update: 1999-07-01