冠心病患者血浆神经肽Y水平变化及其临床意义(PDF)
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2000年第1期
- 页码:
- 13-15, 19
- 栏目:
- 论著
- 出版日期:
- 2000-01-25
文章信息/Info
- Title:
- Change of plasma neuropeptide Y level in patients with coronary heart disease and it′s clinical significance
- Author(s):
- LIU Run-mei; ZHANG Zhi-shou; CHEN Su-juan; TONG Wan-ren; LI Zhen-jia
- Department of Internal Medicine, No.304 Hospital, PLA, Beijing 100037, China
- Keywords:
- coronary disease; myocardial infarction; acute; angina; unstable; neuropeptide Y; radioimmunoassay
- 分类号:
- R543.2
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的 研究不同类型冠心病患者发病不同阶段血浆神经肽 Y(NPY)水平的变化 ,探讨其与冠心病心肌缺血的关系。方法 选急性心肌梗死、不稳定型心绞痛、稳定劳力型心绞痛、陈旧性心肌梗死患者各 30余例发病不同阶段血浆 NPY浓度 ,并选 32例健康者作为对照组。结果 急性心肌梗死急性期 (24h) ,不稳定型心绞痛患者疼痛发作期血浆 NPY水平均明显高于对照组 ,差异非常显著。稳定劳力型心绞痛患者 ,陈旧性心肌梗死患者血浆 NPY水平与对照组比较差异无显著性意义。不稳定型心绞痛患者疼痛发作期血浆 NPY水平高于治疗后 2周病情稳定期 ,差异非常显著 (P<0 .0 1)。急性心肌梗死患者血浆 NPY水平在心梗后 8h左右开始升高 ,2 4h达高峰 (34 6 .2± 5 9.6 pg/ ml) ,7d左右恢复至正常水平(228. 1±38. 6 pg?m l)。结论 冠心病患者出现心肌急性缺血时, 血浆NPY水平升高, 提示NPY参与了冠心病患者急性心肌缺血时的病理生理过程, NPY可作为观察冠心病患者病情变化的一项指标。
- Abstract:
- Objective To investigate the plasma Neuropeptide Y(NPY) concentration in patients with coronary heart disease:acute myocardial infarction (AMI),unstabe angina (UA),stable angina pectoris (SAP),old myocardial infarction (OMI),and to study the relationship between the plasma NPY level and the myocardial ischemia. Methods The plasma NPY concentration of 30 patients with AMI,32 patients with UA,35 patients with SAP,31 patients with OMI and 32 normal controls was determined by radioimmunoassay (RIA). Resu lts The plasma NPY level in patients with AMI (24 h) , in patients with UA when angina attacked is significantly higher than that of healthy controls. The plasma NPY level in patients with SAP, in patients with OMI is not significantly different to that of healthy controls. The N PY level of patient s with UA w hen angina at tacked is significantly higher than that after 2 week treatment (P < 0. 01). The N PY level of patients with AMI is elevated from 8 h after AMI. It reached the peak level at 24 h and declined to normal in 7 d. Conclusion When the patients with coronary heart disease were occurring acute myocardial ischemia, the plasma level of NPY w as elevated. This suggests NPY may participate the pathophysiological course of myocardial ischemia. The plasma NPY level may be a marker for judge the myocardial ischemia status of CHD patients.
参考文献/References
[1] Tatemo to K, Carlquist M, Mutt W. Neuropeptide Y: a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide[J]. Nature, 1982, 296: 659.
[2] Dasgaard C, F ranco J , Saria A , et al. Distribution and origin of substance P-and neuropeptide Y-immunoreactive nerves in the guinea-pig heart[J]. Cell Tissue Res, 1986, 243: 477.
[3] Bishop VS, Malliani A, Thoren P, et al. Handbook of physiology [M]. Bechesds Mary land America: Sheppard RS, 1988: 497～ 555.
[4] Maturi M, Graene R, Speir C, et al. Neuropep tide Y: a peptide found in human coronary arteries constricts primarily small coronary arteries to producemyocardial ischemia in dogs[J]. J Clin Invest, 1989, 83: 1217.
[5] Clarke JG, Davies GJ, Kerwin R, et al. Coronary artery infusion of neuropeptide Y in patients wth angina pectories [J]. Lancet, 1987, I(8541) : 1057.
[6] 曾春雨. 神经肽Y在血管系统中的作用[J]. 心血管病学进展, 1997, 18 (3) : 164.
[7] 付小锁, 张景艳. 神经肽Y 及其作用[J]. 生理科学进展,1993, 24 (2) : 152.
[8] 成 蓓, 张银环, 吴剑萍, 等. 冠心病患者血浆神经肽Y 水平的临床观察[J]. 临床心血管病杂志, 1995, 11 (2) : 73.
[9] Omland T, Opstad PK, Dickstein K, et al. Plasma neuropeptide Y levels in the acute and early convalscent phase aftermyocardial infarction[J]. Am Heart J , 1994, 127 (4 Par) : 774.
[10] Ericsson A , Hemsen A , JanM , et al. Detcetion of neuropeptide Y-like immunoreactivity and messenger RNA in rat platelets: the effects of vinblastine, Reserpine, and Dexamethasone in NPY expression in blood cells [J]. Exp Cell Res, 1991, 192: 604.
备注/Memo
- 备注/Memo:
- 收稿日期：1999-08-03.
常用功能
统计/Statistics
- 摘要浏览/Viewed1141
- 全文下载/Downloads817
- 评论/Comments
