我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

一种新的在体犬冠状动脉定量缺血模型(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第1期
页码:
20-22
栏目:
论著
出版日期:
2000-01-25

文章信息/Info

Title:
A new in vivo coronary artery quantitative ischemia model in dogs
作者:
王跃民;  臧益民;  朱妙章
第四军医大学生理学教研室, 陕西 西安 710032
Author(s):
WANG Yue-min;  ZANG Yi-min;  ZHU Miao-zhang
Department of Physiology Fourth Military Medical University Xi′an 710032 Shaanxi China
关键词:
血压;  灌注压;  冠脉流量;  心肌缺血;  动物实验;  狗
Keywords:
Blood pressure;  pressure of perfusion;  Coronary blood flow;  Myocardial ischemia;  Animal experiment;  dogs
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
作者采用犬冠状动脉灌流的方法 ,以犬颈动脉插管取血 ,经恒流泵从左旋支或前降支主干插管灌入 ,利用恒流泵来控制冠脉流量 ,实现不同程度心肌缺血的实验模型。经测定犬的主动脉压力与左旋支主干压力基本一致(t检验无显著差异 ) ,且主动脉压力较左旋支分支压力高出 1.30 k Pa,因此知道了正常主动脉压力 ,即可确定正常的冠脉压力或冠脉分支小动脉压力 ,同时又可确定正常的冠状动脉血流量。此方法不影响正常状态下的心脏功能 ,用恒流泵的控制旋扭按要求增加或减少灌流量 ,从而建立不同程度的心肌缺血模型。本实验方法不仅成本低 ,而且减少了中间环节 ,使实验的稳定性和准确性都有较大提高 ,并可进行定量分析。
Abstract:
A new in vivo coronary artery quantitative ischemia model in dogs was performed by using the method of intracoronary artery perfusion which was controlled by the constant flow pump.We measured the pressure of aortic artery and the main branch of left circumflex coronary artery by inserting two catheters in cervical artery and the small branch of left circumflex coronary artery respectively. There were no significant difference between them, the pressure of aortic artery was 1.3 kPa higher than that of normal left circumflex, so the normal perfusion pressure of coronary artery was determined by the pressure of aortic artery, and the blood flow of the normal coronary artery can also be determined. Normal cardiac function was not affected, the quantitative myocardial ischemia was controlled by the constant flow pump. This method was simple and inexpensive, the accuracy and stability was imp roved and quantitative analysis was available.

参考文献/References

[1]　郭　鹞. 人类疾病动物模型[M]. 第二辑. 北京: 人民卫生出版社, 1990: 85～ 97.

[2]　宋来风, 章志前. 离体大鼠心脏冠状动脉结扎缺氧模型的探讨[J]. 中华心血管病杂志, 1980, 8 (3) : 215.

[3]　田边恒义. 心脏药理实验方法[M ]. 丸善株式会社, 1981: 14～22.

[4] 　施新猷. 医学动物实验方法[M]. 北京: 人民卫生出版社,1980: 316～ 318.

[5]　朱妙章, 臧益民, 钱学贤, 等. 冠状动脉狭窄和心缩间期的对照研究[J]. 第四军医大学学报, 1989, 10 (4) : 238.

[6]　陈士良, 李兰荪, 朱妙章, 等. 实验性冠状动脉定量狭窄的方法[J]. 中国循环杂志, 1989, 4 (4) : 252.

备注/Memo

备注/Memo:
收稿日期：1999-05-16.
更新日期/Last Update: 2000-01-25