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|本期目录/Table of Contents|

心肌延迟整流钾电流Ik 动力学机制的计算机重建(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第4期
页码:
255-256
栏目:
论著
出版日期:
2000-08-01

文章信息/Info

Title:
Kinetics reconstruction of cardiac delay rectifier K+ current
作者:
商立军1;  臧益民1;  臧伟进2;  王跃民1
1. 第四军医大学基础部生理学教研室, 陕西西安710032;2. 西安医科大学心血管生理药理教研室
Author(s):
SHANG Li-jun 1;  ZANG Yi-min1;  ZANG Wei-jin2;  WANG Yao-min1
1.Department of Physiology, Fourth Military Medical University, Xi′an, 710032, Shaanxi, China; 2.Division of Cardiovascular Physiology and Pharmacology, Xi′an Medical University
关键词:
计算机重建;  延迟整流钾电流;  开关因子
Keywords:
computer reconstruction;  delay rectifier K + current;  open close factor
分类号:
R331.38, TP391.9　
DOI:
-
文献标识码:
A
摘要:
目的 建立能模拟心肌延迟整流钾电流Ik 的数学模型。方法 用计算机重建技术实现动力学机制的模拟。结果 重建了心肌延迟整流钾电流Ik 的通道电流、开关因子动态过程及I2V 曲线。结论 该模型能有效模拟心肌延迟整流钾电流的动力学机制。
Abstract:
AIM To develop a mathematical model for simulating cardiac delay rectifier K + current. METHODS The computer reconstruction was used to simulate the kinetics. RESUITS Cardiac delay rectifier K + current, kinetic process of open close factors and current voltage curve were reconstructed. CONCLUSION The developed model was an effective means to simulate the kinetics of cardiac delay rectifier K + current.

参考文献/References

[1] Shibasaki T. Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart [J]. J Physiol (Lond), 1987, 387: 227.

[2] McDonaid TF, Trautwein W. The potassium current underlying delayed rectification in cat ventricularmuscle[J]. J Physiol (Lond ), 1978, 274: 217.

[3] Matsuura H, Ehara T, Imoto Y. An analysis of the delayed outward current in single ventricular cells of the guinea pig[J]. Pflugers Arch, 1987, 410: 596.

[4] Chinn K. Two delayed rectifier in guniea-pig ventricular myocytes distinguished by tail current k inetics [J]. J Pharmacol Exp Ther, 1993, 264: 555.

[5] Zeng JL, Laurita KR, Rosenbaum DS, et al. Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea-pig Type[J ]. Circ Res, 1995, 77: 140.

[6] Liu GR, Feng JL, Yue LX, et al. Evidence for two components of delayed rectifier K+ current in human ventricular myocytes[J]. Circ R es, 1996, 78: 689.

备注/Memo

备注/Memo:
收稿日期：1999-11-01.
更新日期/Last Update: 2000-08-01