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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2000年第4期

页码:

265-266

栏目:

论著

出版日期:

2000-08-01

文章信息/Info

Title:

Distribution of estrogen receptor in the vascular of rat and rabbit

作者:

胡玉珍¹;  张庆红¹;  张万会¹;  陈亚琼²;  赵玉峰¹;  高瞻¹

第四军医大学: 1 基础部生理学教研室, 2 西京医院妇产科, 陕西西安710032

Author(s):

HU Yu-zhen¹;  ZHANG Qing-hong¹;  ZHANG Wan-hui¹;  CHEN Ya-qiong²;  ZHAO Yu-feng¹;  Gao Zhan¹

1.Department of Physiology; 2.Department of Obstetric & Gynecology, Xijing Hospital, Fourth Military Medical University, Xi'an Shaanxi 710032, China

关键词:

血管; 受体; 雌激素; 免疫组织化学; 大鼠; 兔

Keywords:

vascular;  receptors; estrogen;  immunohistochemistry;  rat;  rabbit

分类号:

Q578

DOI:

-

文献标识码:

A

摘要:

目的 观察ER两个亚型α和β在大鼠和兔血管的表达。方法 应用种属特异性抗体（兔抗大鼠ER α和羊抗大鼠ER β抗体）进行免疫组织化学染色。结果 ERα和ERβ免疫反应阳性物质位于细胞核内，阳性细胞主要分布于血管内膜、外膜及肌层。结论 在大鼠和兔血管分布有ERα和ERβ免疫反应阳性细胞，提示两者在介导雌激素的作用中有重要功能。

Abstract:

AIM To study the distribution of estrogen receptor α and β in the blood vessel of rats and rabbits. METHODS The immuno-histochemical technique was used. RESULTS ER α-immunoreactive(ir) and ER β-ir production was shown in the nucleus. ER α-ir cells are seen in the intima, media and tunica adventitia of blood vessel. ER β-ir are dispersed in the intima and tunica adventitia of rabbit and rat. CONCLUSIONS The two subtypes of estrogen receptor are distributed in the blood vessel of rats and rabbits. It suggests that they play impontant role in mediating the effect of estrogen in the blood vessel.

参考文献/References

[1] Karas RH, Patterson BL, Mendelsohn ME. Human vascular smooth muscle cells contain functional estrogen receptor［J］. Circulation, 1994, 89(5): 1943.

［2］ Grohe C, Kahlert K, Van EM, et al. Effects of moediprilat on oestrogen-stimulated cardiac fibroblast growth［J］. Br J Pharmacol, 1997,121(7):1350.

［3］ Mikkola T,Viinikka L,Ylikorkala O. Estrogen and postmenopausal estrogen/progestin therapy: effect on endothelium-dependent prostacyclin, nitric oxide and endothelin-1 production［J］. Eur J Obstet Gynecol Reprod Biol,1998,79(1): 75.

［4］ Perrot J,Applanat M. Estrogen receptors in the cardiovascular system［J］. Steroids,1996, 61(4): 215.

［5］ Rubanyi GM,Freay AD, Kauser K et al. Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. Gender difference and effect of estrogen receptor gene disruption［J］. J Clin Invest, 1997, 99(10): 2429.

备注/Memo

备注/Memo:

收稿日期：2000-05-09.

常用功能

更新日期/Last Update: 2000-08-01