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急性心肌梗死患者血清磷酸激酶同功酶、肌钙蛋白Ⅰ及肌红蛋白浓度变化的比较研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第4期
页码:
287-288, 292
栏目:
论著
出版日期:
2000-08-01

文章信息/Info

Title:
A comparative study on isoenzyme of serum creatin phosphokinase,cardiac troponin I and myoglobin concentration in patients with acute myocardial infarction
作者:
裴德安;  徐默玲;  郑义通;  胡世文
无锡市第二人民医院心内科, 江苏无锡214002
Author(s):
PEI De-an; 　XU Mo-ling; 　ZHENG Yi-tong; 　HU Shi-wen
Department of Cardiology,Second People′s Hospital of Wuxi,Wuxi Jiangsu 214002,China
关键词:
肌酸激酶同功酶类; 肌钙蛋白I; 肌红蛋白; 心肌梗死; 急性
Keywords:
creatine kinase isoenzymes;  troponin I; myoglobin; myocardial infarction; acute
分类号:
R542.22
DOI:
-
文献标识码:
A
摘要:
目的 比较心脏标记物肌钙蛋白I(CTnI),肌红蛋白(Myo)在急性心肌梗死(AMI)的动态变化,以探讨其诊断价值。方法 用固相双位点化学发光酶联免疫测定法测定了13例AMI患者(5例溶栓再通、8例未溶栓)CTnI,Myo并与CK-KB进行比较。结果 ①溶栓与未溶栓组CTnI在AMI胸痛后升高时间较CK-MB早(均P＜0.01),但以Myo升高时间最早;溶栓成功组CK-MB,CTnI和Myo升高时间均较未溶栓组提前(均P＜0.05);②溶栓与未溶栓组Myo达高峰时间较CTnI和CK-MB均早(均P＜0.01),但CTnI与CK-MB达高峰时间相比无显著性差异(P＞0.05);溶栓再通组CK-MB,CTnI及Myo达高峰时间均较未溶栓组提前(均P＜0.05)；③CK-MB,CTnI和Myo 3种生化标记物以Myo最早恢复正常,而以CTnI在血清中持续时间最长。结论 Myo和CTnI在AMI早期诊断中有应用价值,CK-MB,CTnI及Myo 3者结合可以提高对AMI诊断的准确性。
Abstract:
AIM To evaluate the diagnostic value of cardiac troponin I (CTnI) and myoglobin (Myo) in patients with acute myocardial infarction (AMI). METHODS CTnI and CK-MB were detected with solid-phase two-site chemiluminescent enzyme immunometric assay and were compared with CK-MB in 13 patients with AMI (5 patients with thrombolysis and having successful reperfusion,8 patienrts without thrombolysis). RESULTS ① The detection of CTnI was earlier after the onest of chest pain than that of CK-MB (P＜0.01), but the detection of Myo was earlier after the onset of pain than those of CK-MB activity and CTnI activity (P＜0.01). The detections of CK-MB, CTnI and Myo were earlier in patients with thrombolytic treatment than those of CK-MB, CTnI and Myo respectively in patients without thrombolytic treatment. ②The time of the peak value of Myo occurs earlier than those of CTnI and CK-MB (P＜0.01) in patients both with thrombolysis and without thrombolysis; but the time of peak value of CTnI and CK-MB had no significant deviation (P＞0.05); The time of peak value of CK-MB, CTnI and Myo were earlier in patients with thrombolysis than that of CK-MB, CTnI and Myo respectively in patients without thrombolysis (P＜0.05). ③The disappearance of Myo from the plasma after the onset of pain was earlier than those of CTnI and CK-MB in patients both with thrombolysis and without thrombolysis, and the CTnI ctivity disappearance from the plasma was latest in the three biochemical markers. CONCLUSION The detection of Myo and CTnI is helpful in early diagnosis of AMI. We also conclude that the detection of the combination of CK-MB,CTnI and Myo can improve the accuracy of diagnosis in patients with AMI.

参考文献/References

[1] 中华心血管杂志编委会. 急性心肌梗死溶栓疗法参考方案(1996年7月修订)［J］. 中华心血管病杂志,1996,24(5):328.

［2］ Hamm CW. Katus HA. New biochemical markers for myocardial cell injure［J］. Current Opinion Cardiology,1995,10(4):355.

［3］ Bodor GS,Porter S,Landt Y,et al. Development of monoclonal antibodies for an assay of cardiac troponin-I and preliminary results in suspected case of myocardial infarction［J］. Clin Chem,1992,38(11):2203.

［4］ Uji Y,Okabe H,Sugiuchi H,et al. Measurement of serum myoglobin by a turbidimetric latex agglutination method［J］. J Clin Lab Analy,1992,6(1):7.

［5］ Ishii J,Normura M,Ando T,et al. Early detection of successful coronary reperfusion based on serum myoglobin concentration:comparison with serum creatine kinase isoenzyme MB activity［J］. Am Heart J,1994,128(4):641.

［6］ Mair J,Genser N,Morandell D,et al. Cardiac troponin I in the diagnosis of myocardial injure and infarction［J］. Clin Chem Acta,1996,245(1):19.

备注/Memo

备注/Memo:
收稿日期：1999-07-05.
更新日期/Last Update: 2000-08-01