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|本期目录/Table of Contents|

高血压病左室结构功能变化与血浆内皮素的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第6期
页码:
455-457
栏目:
论著
出版日期:
2000-12-01

文章信息/Info

Title:
The relationship between changes in left ventricular structure and function,and the plasma endothelin in essential hypertension
作者:
黄织春1;  刘凤琴1;  郝　富2
1. 内蒙古医学院附属医院心内科, 内蒙古呼和浩特010050; 2. 内蒙古自治区卫生厅
Author(s):
HUANG Zhi-chun1;  LIU Feng-qing1;  HAO Fu2
1.Department of Cardiology, Affiliated Hospital of Neimenggu Medical College, Huhehaote Neimenggu 010050, China; 2.Deparment of Health, Neimenggu
关键词:
高血压;  左室肥厚;  心室功能;  内皮素
Keywords:
hypertension;  left ventricular hypertrophy;  cardiac function;  endothelin
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨高血压病患者左室结构 ,功能变化与血浆内皮素 (ET)的关系。方法 原发性高血压不伴左室肥厚(L VH)组 (EH) 35例 ,伴 L VH组 (EH+ L VH) 2 8例 ,正常对照组 30例。放射免疫法测定血浆 ET水平 ,超声心动图检测心脏结构与功能。计算左室重量指数 (L VMI) ,平均室壁厚度 (MWT) ,相对室壁厚度 (RWT)。结果 EH组及 EH+ L VH组血浆 ET高于正常对照组 (P<0 .0 1) ,EH + L VH组 ET高于 EH组 (P<0 .0 1) ,ET与 L VMI,MWT室间隔厚度 ,左室后壁厚度呈正相关 (r分别为 0 .42 4,0 .316 ,0 .2 6 8和 0 .317,均 P<0 .0 1) ,ET与 E/ A呈负相关 (r=-0 .30 4,P<0 .0 1)。结论 ET与高血压和 LVH相关。
Abstract:
AIM To investigate the relationship between the plasma endothelin(ET) and the left ventricular structure and function in essential hypertension(EH). METHODS 35 EH patients without left ventricular hypertrophy (LVH),28 EH patients with LVH and 30 normotensive controls were studied. Plasma ET levels were detected by radioimmunoassay (RIA). Color Doppler echocardiography was used to study left ventricular structure and function. Left ventricular mass index(LVMI). mean ventricular wall thickness (MWT) and relative wall thickness (RWT ) were calculated. RESULTS Plasma ET levels in hypertensive patients with and without LVH were significantly higher than those in normotensive controls (P < 0. 01). Plasma ET levels in patients with LVH were significantly higher than those in patients without LVH (P < 0. 01 ). There were significant correlations between ET and left ventricular mass index (LVMI), interventricular septal thickness (IVST), postterior wall thickness (PWT ) (all P < 0.01, r= 0. 424, 0.316, 0. 268, 0. 317, respectively). There was a negative correlation between the plasma ET and E/A ratio ( r= - 0. 304, P < 0. 01). CONCLUSION The level of ET is related to EH and LVH.

参考文献/References

[1] Devereux RB, Alonso DR. Lutas EM, et al. Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings[J]. Am J Cardiol, 1986, 57 (6) : 450.

[2] Yanagisawa M , Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide producted by vascular endothelial cells[J]. Nature, 1988, 332 (6163) : 441.

[3] 毕万里, 谢选珠, 吴　敬, 等. 内皮素对心血管系统内血管紧张素II的影响[J]. 生理学报, 1990, 42 (3) : 248.

[4] 汤　健, 唐朝枢, 李兆萍, 等. 内皮素对大鼠心血管功能的影响[J]. 生理科学, 1989, 9 (3) : 150.

[5] 唐朝枢, 谢选珠, 汤　健. 内皮素[J ]. 北京医科大学学报, 1989,21 (2) : 163.

备注/Memo

备注/Memo:
收稿日期：1999-12-06.
更新日期/Last Update: 2000-12-01