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高氧液对家兔心肌缺血再灌注损伤的保护作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第1期
页码:
25-26
栏目:
论著
出版日期:
2001-01-25

文章信息/Info

Title:
Protective effect of hyperoxia liquid on myocardial ischemia reperfusion
作者:
孙绪德1; 柴伟1; 马家海2;  徐礼鲜2;  胡敏2
第四军医大学：1．唐都医院麻醉科，陕西西安710038．2．秦都口腔医学院麻醉科
Author(s):
SUN Xu-de ; CHAI Wei ; MA Jia-hal ; XU Li-xian ;  HU Min
1.Department of Anesthesiology，Tangdu Hospital，Xi'an 710038． China，2．Department of Anesthesiology，Qindu Stomatological College，Fourth Military Medical University
关键词:
心肌再灌注损伤; 高氧液; 氧自由基; 动物模型
Keywords:
myocardial reperfusion injury; hyperoxia liquid; oxygen-derived free radicals; animal mode
分类号:
R972
DOI:
-
文献标识码:
A
摘要:
目的 观察高氧液对家兔心肌缺血再灌注损伤的保护作用．方法 结扎免冠状动脉左室支中段，40rain后解除结扎行再灌注，制成心肌急性缺血再灌注模型。于缺血前10 min、再灌注前10 min，分别静滴平衡盐液、高氯平衡盐液，观察在急性缺血及再灌注状态下心电图、血浆肌酸磷酸激酶(CK)、丙二醛(MDA)和超氧化物歧化酶(SOD)的变化。结果 高氧平衡盐液能使抬高的心电图S-T段明显下降，缺血再灌注心肌CK活性明显降低；并能保护SOD的活性，降低脂质过氧化反应代谢产物MDA的含量。结论 高氧平衡盐液对家兔在体心肌缺血再灌注损伤具有明显的保护作用。
Abstract:
AIM To investigate the protective effect of hyperoxia on myocardial ischemia reperfusion．METHODS Rabbit s ischernia reperfusion model was carried out by ligation of left anterior coronary descending and removing the ligation after 40 min．Balanced salt solution (BSS)(group I)and hyperoxia liquid (group I)were given，perfusion 10 min before ischemia of myocardium．perfusion 10 min before reperfusion，respectively．The changes of electrocardiogram ，activity of CK and amount of MDA and SOD in plasma were observed following acute ischemia and reperfusion． RESULTS In group I，the elevated of S—T segment in electrocardiogram which was caused by myocardial ischemia was attenuated，and activity of CK in myocardial ischemia reperfusion was lower than that of the other group-The amount of SOD was significantly higher in group 1 than in group I，while the amount of MDA in group 1 was lower significantly．CONCLUSION The hyperoxia liquid has obviously protective’effects on myocardial ischemia reperfusion．

参考文献/References

[1]Carajal K，EI-Gafidi M,El-Gafidi M,Banos G．Myocardial damage due to ischemia and reperfusion in hypertriglyceridemic and hypertensive ret:participation of free radicals and calcium overloa[J]．J Hypertens，1999，17(11):1607— 1616．

[2]Okabe E．Superoxide anion radical selectively increases Ca release from cardiac sarcoplasmic reticulum through ryanodine receptor Ca channe[J]．Nipon Yakurigaku Zasshi，1998．112(sappl 1):58-62．

[3]Dart RC,Sanders AB，Oxygen free radicals and myocardial reperfusion injury[]J．Ann Emery，1988．17(2):53．

[4]Flitter WD, Siompson PJ，Lucchcei BR．Free rad／cal and myoeardialrel reperfusion injurt[J]．Br Mid ．1994．49 (9):545．

[5]Vanden HT，Lj C．shao Z．Sfagaificant levels of oxidants generated by isolated cardlomyocytea during iachemia prior to reperfusion[J]．J Mol Cell Cardiol．1997，29(9):2571-2583．

[6]Kramer JH Lipid peroxidation-derived free radical production and postischemic myocardial reperfusion injury[J]．Ann NY Acad Scl．1994，723 (10):258．

[7]Paradies G．petrosillo G，Pistcies M．Lipid peloxidafiem and alterations to oxidative metabolism in mltochondfia isolated from／rat heart sutIjected to ischemis snd reperfusion[J]．Fret Radic Biol Med．1999，27(1～2:42-5O．

备注/Memo

备注/Memo:
收稿日期：2000-03-15.基金项目：陕西省自然科学基金(No．99SM99)
更新日期/Last Update: 2001-01-25