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冠心病患者血清肿瘤坏死因子、白细胞介素-6水平及其关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第3期
页码:
173-174, 177
栏目:
论著
出版日期:
2001-05-01

文章信息/Info

Title:
Study of serum TNF,IL-6 levels in patients with coronary heart disease and their relationship
作者:
杜登贵;  何海明;  施根林
武警江苏总队医院心内科, 江苏扬州225003
Author(s):
DU Deng-gui;  HE Hai-ming;  SHI Gen-lin
Department of Cardiology, Jiangsu Provincial Corp Hospital, Chinese People′s Armed Police Force, Yangzhou Jiangsu 225003, China
关键词:
冠状动脉疾病;  肿瘤坏死因子;  白细胞介素-6
Keywords:
coronary disease;  tumor necrosis factor;  interleukin-6。
分类号:
R542.22
DOI:
-
文献标识码:
A
摘要:
目的 观察冠心病 (CHD)患者血清肿瘤坏死因子 (TNF)、白细胞介素 - 6 (IL- 6 )的变化与临床意义。方法 采用放射免疫分析法 (RIA)测定 45例 CHD患者及 30例健康者 (对照组 )血清 TNF,IL- 6水平。结果 CHD患者血清TNF,IL- 6水平均显著高于对照组 (P<0 .0 1) ,尤以心肌梗死患者为明显 (P<0 .0 1) ;心肌梗死组血清 TNF,IL- 6水平较心肌缺血组显著升高 (P<0 .0 1) ;急性心肌梗死患者血清 TNF,IL- 6水平高于陈旧性心肌梗死患者 (P<0 .0 5 ) ;心肌缺血组心功能 ～ 级患者血清 TNF,IL- 6水平较心功能 ～ 级患者升高显著 (P<0 .0 1) ;血清TNF水平与 IL- 6之间呈明显正相关 (r=0 .73,P<0 .0 1)。结论 血清 TNF,IL- 6水平与 CHD病情严重程度密切相关 ,TNF,IL- 6可能参与 CHD的发生与发展。
Abstract:
AIM To study the changes of serum tumor necrosis factor(TNF) and interleukin 6 (IL-6) in patients with coronary heart disease (CHD) and their clinical significance. METHODS The serum TNF and IL-6 in 45 patients with CHD and in 30 healthy controls were determined by using radioimmunoassay (RIA). RESULTS The serum TNF and IL 6 levels in patients with CHD were markedly higher than those in the controls ( P <0.01),and especially those in patients with myocardial infarction were more obvious ( P <0.01). The serum TNF and IL-6 levels in myocardial infarction were much higher than those in myocardial ischemia (P<0.01). In patients with myocardial infarction, the serum TNF and IL-6 levels in AMI patients were higher than those in OMI patients (P<0.05). In myocardial ischemia patients, the serum TNF and IL 26 level at heart function stages III～ IV, were higher than those at heart function stages I～ II (P < 0. 01). The serum TNF level was obvious positively correlated with IL 26 ( r= 0. 73, P < 0. 01). CONCLUSION The levels of serum TNf and IL-6 are closely related to the severity of CHD. The study has implied that TNF and IL-6 may contribute to the formation and progression of CHD.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2000-08-09.
更新日期/Last Update: 2001-05-01