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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2001年第3期

页码:

198-200, 203

栏目:

论著

出版日期:

2001-05-01

文章信息/Info

Title:

Influence of isoprenaline on the cardiovascular effects caused by sevoflurane in dogs

作者:

侯立朝¹;  张 宏²;  熊利泽¹;  张高魁³;  靳 冰²;  陈绍洋¹

1.第四军医大学西京医院麻醉科,陕西西安710032;解放军总医院:2.麻醉科,3.统计学教研室,北京100853

Author(s):

HOU Li-chao¹;  ZHANG Hong²;  XIONG Li-ze¹;  ZHANG Gao-kui³; JIN Bing²; Chen Shao-yang¹

1.Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi' an Shaanxi 710033,China; 2. Department of Anesthesiology, 3.Department of Statistics, General Hospital of PLA, Beijing 100853, China

关键词:

异丙肾上腺素; 七氟醚; 心血管系统

Keywords:

Isoproterenol;  Sevoflurane;  Cardiovascular system

分类号:

R971.2

DOI:

-

文献标识码:

A

摘要:

目的 探讨异丙肾上腺素(ISP)对七氟醚的心血管效应的影响。方法 本实验分为七氟醚低浓度[1.45vol%,0.6 MAC(最小肺泡有效浓度)]和高浓度(2.90vol%,1.2 MAC)两部分。32只健康杂种犬被随机分为四组(每组8例):对照组、七氟醚组、ISP组和ISP+七氟醚组。监测有创动脉血压、肺动脉压、肺动脉楔压、中心静脉压、心输出量和心率。记录上述参数在用药20 min后的变化。结果 在硫喷妥钠麻醉犬上静脉滴注0.02μg·kg-1·min-1的ISP和0.6MAC及1.2MAC七氟醚的心血管效应之间均没有交互作用。结论 ISP对临床浓度的七氟醚的心血管效应没有显著影响。

Abstract:

AIM To explore the influence of isoprenaline on cardiovascular effects caused by sevoflurane.METHODS This study included two parts: low-concentration sevoflurane and high-concentration sevoflurane. 32 healthy dogs were randomly divided into four groups (n=8 for each group): Sevoflurane+isoprenaline group, Isoprenaline group, Sevoflurane group, Con-trol group. Invasive arterial blood pressure, pulmonary arterial pressure, pulmonary wedge pres-sure, centravenous vein pressure, cardiac output as well as heart rate were monitored in all dogs. RESULTS In thiopentalanesthetized dogs, no interaction existed between the cardiovascular ef-fects caused by sevoflurane either in 1.45vol% (0.6MAC) or 2.90vol% (1.2MAC) and the cardiovascular effects caused by intravenous isoprenaline at the rate of 0.02μg·kg-1·min-1.CONCLUSOIN: Isoprenaline had no significant influence on its cardiovascular effect caused by sevoflurane.

参考文献/References

[1] Hanouz JL, Vivien B, Gueugniaud PY,et al. Interaction of isoflurane and sevoflurane withα-andβ-adrenoceptor stimulations in rat myocardium[J].Anesthesiology, 1998, 88(5): 1249-1258.

[2] Hanouz JL, Riou B, Massias L,et al. Interaction of halothane withα-andβ-adrenoceptor stimulations in rat myocardium[J].Anesthesiology, 1997,86(1): 147-159.

[3] Kazema T, Ikeda K. Comparison of MAC and the rate of rise of alveolar concentration of sevoflurane with halothane and isoflurane in the dog[J].Anesthesiololgy, 1988, 68(3): 435-437.

[4] Steinberg C, Notterman DA. Pharmacokinetics of cardiovascular drugs in children: inotropes and vasopressors [J].ClinPharmacokinet, 1994, 27(5): 345-367.

[5] Ebert TJ, Harkin CP, Muzi M. Cardiovascular responses tosevoflurane: a review[J].Anesth Analg, 1995, 81(6 Suppl):S11-S22.

[6] Sanuki M, Yuge O, Kawamoto M,et al. Sevoflurane inhibited β-adrenoceptor-G protein bindings in myocardial membrane in rats[J].Anesth Analg, 1994, 79(3): 466-471.

[7] Wheeler DM, Katz A, Rice RT,et al. Volatile anesthetic effects on sarcoplasmic reticulum Ca content and sarcolemmal Caflux in isolated rat cardiac cell suspensions[J].Anesthesiology, 1994, 80(2): 372-382.

[8]李树人,韩如泉,槐庆元.七氟醚对犬血流动力学影响的实验研究[J].中华麻醉学杂志,1996,16(11): 543-546.

[9] Davies LA, Hamilton DL, Hopkins PM,et al. Concentration-dependent inotropic effects of halothane, isoflurane and sevoflurane on rat ventricular myocytes[J].Br J Anaesth, 1999, 82(5): 723-730.

[10]侯立朝,张宏,熊利泽,等.七氟醚和异氟醚心血管效应的比较[J].第四军医大学学报,2000,21(11):1363-1366.

备注/Memo

备注/Memo:

收稿日期：2000-12-26.

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更新日期/Last Update: 2001-05-01