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冠状动脉内磁化支架置入术后冠状静脉窦血中NO与ET-1水平的变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第3期
页码:
201-203
栏目:
论著
出版日期:
2001-05-01

文章信息/Info

Title:
Changes in the levels of serum nitric oxide and plasma endothelin-1 in coronary sinus after intracoronary magnetized stent placement
作者:
李家一1;  贾国良1;  吕安林1;  王海昌1;  王小燕1;  赵丽莎2
第四军医大学西京医院:1.心血管内科,2.皮肤科,陕西西安710032
Author(s):
LI Jia-yi1;  JIA Guo-liang1;  LU An-lin1;  WANG Hai-chang1;  WANG Xiao-yan1;  ZHAO Li-sha2
1.Department of Cardiology, 2.Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an Shaanxi 710032, China
关键词:
血管成形术; 经腔; 经皮冠状动脉; 冠状动脉内支架置入术; 磁场; 一氧化氮; 内皮素-1
Keywords:
angioplasty; transluminal; percutaneous coronary;  intrasoronary stent placement;  magnetic field;  nitric oxide;  endothelin-1
分类号:
R454.1
DOI:
-
文献标识码:
A
摘要:
目的 观察冠心病患者冠状动脉内置入磁化支架后冠状静脉窦血中一氧化氮(NO)与内皮素-1(ET-1)水平的变化,探讨磁化支架防治冠状动脉再狭窄的机制。方法 经皮腔内冠状动脉成形术及冠状动脉内支架置入术的冠心病患者随机分为磁化支架组(23例)及非磁化支架对照组(16例)。经股静脉将6F右冠状动脉造影导管置入冠状静脉窦采血,采用Griess法及非平衡法分别测定冠状动脉内支架置入术前及术后6 h内冠状静脉窦血中NO及ET-1的水平。结果 磁化支架组术后6 h冠状静脉窦血中NO含量较对照组相比显著升高(P<0.01);磁化支架组ET-1水平的改变,包括术后即刻降低P<0.01)与6 h回升(P<0.01)都不如对照组明显,两组ET-1水平在3 h有显著性差异(P<0.05)。结论:冠状动脉内磁化支架置入术后NO升高与ET-1水平变化趋缓反映了靶区血管局部内皮细胞功能改善,磁化支架置入术后急性冠脉痉挛及远期冠脉再狭窄的发生率降低可能与此有关。
Abstract:
AIM To investigate the effects of intracoronary magnetized stent placement on the level of serum nitric oxide (NO) and plasma endothelin-1(ET-1) in coronary sinus in patients with coronary heart disease after percutaneous transluminal coronary angioplasty (PTCA). METHODS Patients with coronary heart disease randomly received magnetized or unmagnetized stent placement as controls. Placing a right coronary artery catheter into the coronary sinus, we collected blood samples of the patients during the first 6 h after PTCA and stent placement. Levels of serum NO and plasma ET-1 were determined by Griess method and non-balanced method.RESULTS Serum level of NO of the magnetized-stent patients was significantly higher than that of the controls(P<0.01), while plasma level of ET-1 didn' t change as markedly as the controls (P<0.05). CONCLUSION Higher level of NO and smooth changes of ET-1 level reflect the improvement of endothelial cell function after magnetized stent placement, which may play some role in the reduction of acute coronary spasm and long-term restenosis.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2000-12-27.
更新日期/Last Update: 2001-05-01