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心肌细胞Ca~(2+)信号与心肌肥厚研究新进展(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第3期
页码:
224-226
栏目:
综述
出版日期:
2001-05-01

文章信息/Info

Title:
-
作者:
杨永健1;  祝善俊1;  祝之明2
1.第三军医大学新桥医院心内科,重庆400037;2.第三军医大学大坪医院高血压内分泌科
Author(s):
-
关键词:
Ca2+信号; Ca2+超载; 心肌肥厚; 心律失常
Keywords:
-
分类号:
R322.11
DOI:
-
文献标识码:
A
摘要:
心肌细胞内Ca2+信号形成涉及胞外Ca2+的内流及内贮Ca2+的释放。Ca2+信号以多种形式表现如钙微粒、钙闪烁、钙波、钙振荡、全细胞性瞬时性钙增高等。Ca2+信号主要是通过钙振荡或钙跃升的频率来编码外来信息,钙峰的幅度、持续时间及Ca2+信号的空间位置均参与对外来信息的编码。异常的Ca2+信号编码与心肌肥厚关系密切,肥厚的心肌钙转运异常导致Ca2+超载加重,使心功能恶化,最终导致心律失常。
Abstract:
-

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2000-06-03.
更新日期/Last Update: 2001-05-01