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雌激素替代治疗对绝经后冠心病妇女血脂和胰岛素抵抗的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第4期
页码:
296-298
栏目:
论著
出版日期:
2001-07-01

文章信息/Info

Title:
Effect of estrogen replacement therapy on dislipidemia and insulin resistance in postmenopausal women with CHD
作者:
李海鹰1;  吴雪清2;  叶碧绿2
温州医学院附属第一医院: 1. 心内科, 2. 妇产科, 浙江温州325000
Author(s):
LI Hai-ying ; WU Xue-qing ;  YE Bi-lu
Affiliated Hosptal,Wenzhou Medical College,Wenzhou Zhejiang 325000, China
关键词:
绝经;  冠状动脉疾病;  雌激素替代治疗
Keywords:
menopause;  coronary disease;  estrogen replacement therapy
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
目的 观察雌激素替代治疗对绝经后冠心病(CHD) 妇女血脂谱和胰岛素抵抗的改善作用。方法 对确诊为CHD 的绝经后妇女, 口服尼尔雌醇2 mg/2 周, 治疗6 个月。分别于治疗前后测定血糖、胰岛素( INS)、性激素结合球蛋白(SHBG)、促卵泡素(FSH)、黄体生成素(LH)、雌二醇(E2)、总胆固醇(T-CH)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C) 等, 并计算胰岛素敏感指数(SI)。结果 雌激素替代后, CHD 患者的FSH,LH, T-CH, TG,LDL-C, INS 明显下降; 而E2, SHBG,HDL-C, SI 明显升高。结论 雌激素替代治疗能改善CHD 患者血脂谱紊乱和胰岛素抵抗。
Abstract:
AIM To observe the role of estrogen replacement of improvement of dislipidemia and insulin resistance in postmenopausal women with coronary heart diseases (CHD). METHODS Postmenopausal women who were diagnosed with CHD were included. They were treated with nylestrol 2 mg/2 weeks, and the treatment continued 6 months. The levels of bloodglucose,insulin ( INS ) , sexhormone binding gobulin (SHBG) , follicular stimulating hormone (FSH),luteinhormone (LH) , estrodiol (E2) , total cholesterol (T-CH ) , tryglycerin (TG) , high density lipid cholesterol (HDL-C ) , low density lipid cholesterol (LDL-C ) were measured before and after treatment. RESULTS After treatment, the levels of FSH, LH, T-CH, TG, LDL-C and INS were apparently decreased; while the levels of E2, SHBG, HDL-C, SI were aparently increased. CONCLUSION ERT can improve dislipidemia and insulin resistance in postmenopausal women with CHD.

参考文献/References

[1] Stamper MJ , Colditz GA. Estrogen replacement therapy and coronary heart disease: Aquantitative assessment of epidemiologic evidence[J]. Prev Med , 1991, 20: 47.

[2] 程国均, 刘建立. 绝经后妇女雌激素替代治疗[J]. 中华妇产科杂志, 1995, 3: 123- 127.

[3] Steil GM ,Volund S, Kahn SE, et al. Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model[J]. Diabetes, 1993, 42: 250- 256.

[4]Walsh BW , Schiff I, Rosener B, et al. Effects of postmenopausal estrogen replacement on the concentration and metabolism of plasma lipoprotein [J]. N Engl J Med , 1991, 325: 1196.

[5] Adans MR, Kaplasm JR, Manuck SB, et al. Inhibition of coronary atherosclerosis by 17-B estradiol in ovariectomized monkeys. Lack of effect of added progesteronen [J].Arterisclerosis, 1990, 10: 1051- 1057.

[6] Brussaard HE, Lern JA , Kluft C, et al. Estrogen replacement improves insulin response, lipoproteins and fibrinolysis in women with NIDDM [C]. Proc of the 31st. Annual mecting of the european assocciation for study of diabetes, Stockholm, 1995(Abstract).

[7] Wild RA , Alaupovic P, Parker IJ. Lipid and apolipoprotein abnormalities in hirsute women. The association with insulin resistance[J]. Am J Obstet Gynecol, 1992, 166: 1191- 1196.

备注/Memo

备注/Memo:
收稿日期：2001-02-13.
更新日期/Last Update: 2001-07-01