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|本期目录/Table of Contents|

银杏黄酮与蚓激酶的抗凝溶栓作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第4期
页码:
308-309
栏目:
论著
出版日期:
2001-07-01

文章信息/Info

Title:
Studies on the anti-coagulation and thrombolytic effect of ginkgetin and lumbrici kinase
作者:
陈健康1王雷2李珂2郭峰2杨军2
第四军医大学:1.基础部教学实验中心.2.学员四大队,陕酉西安710032
Author(s):
CHEN Jian-kang1WANG Lei2LI Ke2GUO Feng2YANG Jun2
1.Center of Teaching and Experiments,2,Fourth Student Team ,Fourth Military Medical University,Xi’an Shaanxi 710032,China
关键词:
银杏黄酮蚓激酶抗凝溶栓
Keywords:
-
分类号:
R285
DOI:
-
文献标识码:
A
摘要:
目的 探讨银杏黄酮、蚓激酶及其合用的抗凝溶栓效果。方法 实验分为抗凝和溶栓两部分,每部分再分为银杏黄酮组、蚓激酶组、银杏黄酮与蚓激酶联用组、阿司匹林组及生理盐水对照组。抗凝试验中各组小鼠给与相应药物3 d,剪断鼠尾测定出血时间,溶栓试验的试管中,分别加人约0.2 g血凝块和相应药物,2 h后观察血块溶解情况。结果 银杏黄酮、蚓激酶、银杏黄酮与蚓激酶合用均有良好的抗凝效果,蚓激酶有良好的溶栓效果而银杏黄酮溶栓效果不明显.银杏黄酮与蚓激酶合用溶栓作用没有加强。结论 银杏黄酮和蚓激酶合用有较好的抗凝效果和溶血作用。
Abstract:
AIM Research anti-coagulation and thrombolytic effects of ginkgetin,lumbrici kinase and ginkgetin +lumbrici kinase on mice. METHODS Experiments dividing into 2 parts:anticoagulation effect,thrombolytic effect.Part 1,40 mice were dividing into 5 groups:ginkgetin,lumbricl kinase,gingkgetin + Lumhrici kinase,aspirin and control;Part 2,chicken's blood coagulum dividing into 30 tubes,each tube contain 0.2 g. 30 tubes were dividing into same 5 groups. After 2 h observe the blood coagulum's weight.RESULTS Ginkgetin,lumbrici kinase and ginkgetin + lumbrici kinase have strong effect of anti-coagulation.Lumbrici kinase has better thrombolytic effects,but gingkgetin have a few this effect;if ginkgetin + lumbriei kinase,the thromholytic effect didn't increased.CONCLUSION Ginkgetin + lumbrici kinase used together which have better anti-coagulation and thrombolytie effect in vitro or vivo.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期:2000-12-08.
更新日期/Last Update: 2001-07-01