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|本期目录/Table of Contents|

p27 蛋白与心血管疾病(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第5期
页码:
414-416
栏目:
综述
出版日期:
2001-09-01

文章信息/Info

Title:
-
作者:
陈永清;  赵连友
第四军医大学唐都医院心血管内科, 陕西西安710038
Author(s):
-
关键词:
p27 蛋白;  细胞周期调控;  心血管疾病
Keywords:
-
分类号:
Q71; R54　
DOI:
-
文献标识码:
A
摘要:
p27 蛋白作为细胞周期的负性调节因子, 能抑制细胞增殖, 使其停滞于G1 期。心血管系统中有大量以增殖异常为细胞学本质的疾病, p27 蛋白参与这些疾病的发生、发展, 进一步研究p 27 蛋白的作用将为阐明其发病机制、寻 求有效治疗途径提供重要线索。
Abstract:
-

参考文献/References

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[7] Fukumoto S, Nishizawa Y, Hosiol M , et al. Protein kinase CD inhibits the proliferation of vascular smooth muscle cells by suppressing G1 cyclin expression [J]. J Biol Chem , 1997, 272(21) : 13816- 13822.

[8] 许顶立, 袁　勇, 刘伊丽, 等. 血管紧张素II 和血小板源生长因子对血管平滑肌细胞和心肌细胞细胞周期素及p27 蛋白的不同影响[J]. 中华医学杂志, 1999, 79 (9) : 657- 659.

[9] Antonov AS,Munn DH, Kolodgie FD, et al. Aortic endothelial cells regulate proliferation of human monocytes in vitro via a mechanism synergistic with macrophage colony-stimulating factor[J]. J Clin Invest, 1997, 99 (12) : 2867- 2876.

[10] Chen DH, Krasinski K, Chen DF, et al. Downregulation of cyclin-dependent kinase 2 activity and cyclinA promotor activity in vascular smooth muscle cells by p27, and inhibitor of neointima formation in the rat carotid artery[J]. J Clin Invest,1997, 99 (10) : 2334- 2341.

[11]潘小明, 章卫平, 吴宗贵, 等. 腺病毒介导的人p27Kip1基因高表达对大鼠血管平滑肌细胞增殖的抑制作用[J]. 中华医学杂志,2000, 80 (4) : 312- 313.

备注/Memo

备注/Memo:
收稿日期：2000-03-29.
更新日期/Last Update: 2001-09-01