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|本期目录/Table of Contents|

大鼠心肌组织中5-HT 和AngII含量在心肌肥厚前后的变化

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第6期
页码:
425-426，429
栏目:
论著
出版日期:
2001-11-01

文章信息/Info

Title:
Alteration of 5-HT and AngII content in myocardial tissue of rats with cardiac hypertrophy
作者:
招明高1;  梅其炳1;  张晓霞2;  张晓楠3;  张延凤3;  赵德化1
第四军医大学: 1. 药理学教研室, 3. 中心实验室, 陕西西安710032; 2. 西安市第一人民医院药剂科
Author(s):
ZHAO Ming-gao1; MEI Qi-bing1;  ZHANG Xiao-xia2;  ZHANG Xiao-Nan3;  ZHANG Yan-feng3; Zhao De-hua1
1. Department of Pharmacology, 3. Center Laboratory, Fourth Military Medical University,Xi’an Shaanxi 710032, China; 2. Xi’an 1st People’s Hospital
关键词:
心肌疾病;  5-羟色胺;  血管紧张素II
Keywords:
myocardial deseases;  5-hydrotriptamine;  angiotensin-II
分类号:
R542.3
DOI:
-
文献标识码:
A
摘要:
目的 探讨心肌组织中5-羟色胺(5-HT ) 及血管紧张素II (AngII) 含量与心肌肥厚发生的关系。方法 采用腹主动脉缩窄法建立压力超负荷心肌肥厚模型; 腹腔注射甲状腺素法建立体液性心肌肥厚模型; 荧光分光光度法和放射免疫分析法测定5-HT 及AngII含量。结果 压力超负荷和甲状腺素致心肌肥厚大鼠心肌组织中5-HT 含量较对照组显著增加(298±57 vs 428±58 ng.g-1, P<0. 01; 277±47 vs 362±76 ng.g- 1, P<0. 05); 同样, 在两种心肌肥厚大鼠心肌组织中AngII含量也有不同程度的增加(190±75 vs 323±63 pg.g- 1, P < 0. 01; 167±55 vs 278±46 pg.g- 1, P<0. 01)。结论 提示5-HT 及AngII与压力超负荷和体液性因素致心肌肥厚的形成有关。
Abstract:
AIM To study relation ship between cardiac hypertrophy and content of 5-HT and AngII. METHODS The pressure overload hypertrophy and endocrine hypertrophy models of heart were established respectively by clipping aortaor in jecting thyroxine. Radioimmunoassay and fluorimetric assay were used to measure content of 5-HT and AngII in myocardial tissue. RESULTS In pressure overload and thyroxine induced hypertrophy models the content of 5-HT increased significantly (298±57 vs 428±58 ng.g-1, P<0. 01; 277±47 vs 362±76 ng.g-1, P<0.05), the content of AngII also increased in the two models (190±75 vs 323±63 pg.g-1, P<0.01; 167±55 vs 278±46 pg.g-1, P<0. 01). CONCLUSION The content of 5-HT and AngII and myocardial hypertrophy were associated.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2000-06-30.
更新日期/Last Update: 2001-11-01