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伊贝沙坦对充血性心力衰竭患者细胞因子和血管紧张素Ⅱ的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第3期
页码:
235-237,240
栏目:
临床研究
出版日期:
2002-05-01

文章信息/Info

Title:
Effect of Carvedilol irbesartan on serum cytokine levels and angiotens in Ⅱ in patients with congestive heart failure
作者:
郭　明1;  杨欣国1;  王　亚2
1.第四军医大学唐都医院心内科, 陕西 西安 710038; 2.云南体育运动学校, 云南 昆明 , 650000
Author(s):
GUO Ming1;  YANG Xin-guo1; WANG Ya2
Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710038, China
关键词:
心力衰竭;  充血性;  肿瘤坏死因子;  白细胞介素26;  血管紧张素Ⅱ ;  左心室射血分数;  伊贝沙坦
Keywords:
heart failure;  congestive;  tumor necrosis factor;  interleukin-6;  angiotensin Ⅱ ;  left ventricu lar ejective fraction;  irbesartan
分类号:
R541.1;R972　
DOI:
-
文献标识码:
A
摘要:
目的 观察充血性心力衰竭(CHF)患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、血浆血管紧张素Ⅱ(AngⅡ)的变化以及伊贝沙坦对它们的影响。方法 测定30例健康对照组和66例CHF患者治疗前后TNF-α,IL-6和AngⅡ浓度。66例CHF患者随机分为伊贝沙坦组(n=34)和培哚普利组(n=32),治疗前及治疗后4周用彩色多普勒二维超声显像仪测定左心室射血分数(LVEF)。结果 CHF组血清TNF-α,IL-6和血浆AngⅡ水平明显高于健康对照组,有非常显著性差异(P<0.01)。血清TNF-α,IL-6水平与CHF的原发病无相关,而与LVEF呈负相关(r=-0.58,r=-0.62,P<0.01)。伊贝沙坦组、培哚普利组治疗4周后TNF-α,IL-6水平显著下降,伊贝沙坦组较培哚普利组IL-6显著降低(P<0.05),LVEF显著升高(P<0.05)。结论 CHF患者血清TNF-α,IL-6, AngⅡ水平明显升高,且与LVEF呈负相关。伊贝沙坦具有降低血清TNF-α,IL-6水平及改善LVEF的作用。
Abstract:
AIM To observe serum levels of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6)and angiotensinⅡ( AngⅡ)in patients with congestive heart failure (CHF)and its changes with treatment of irbesartan or perindopril.METHODS Serum concentrations of TNF-α,IL-6 and AngⅡin normal controls (n=30) and patients with CHF(n=66),who were randomized into irbesartan group(n=34) and perindopril group(n=32),were measured before and 4 weeks after treatment respectively.Left ventricular ejective fractions(LVEF) were also estimated in those subjects.RESULTS There was a significant increase in serum levels of TNF-α,IL-6 and AngⅡ in patients with CHF compared with normal controls(P<0.01). The serum levels of TNF-αand IL-6 were negative related to LVEF(r=-0.58,r=-0.62,P<0.05), but not related to primary disease of CHF.There was a significant decrease in serum levels of TNF-αand IL-6 and increase in LVEF(P<0.05) in both irbesartan group and perindopril group,but the decrease of IL-6 in the irbesartan group was significant bigger than that of perindopril group.CONCLUSION There was a significant increase in serum levels of TNF-α,IL-6 and AngⅡin patients with CHF,and the serum levels of TNF-αand IL-6 were negative related to LVEF. Irbesartan decrease the serum levels of TNF-αand IL-6 and increase LVEF in patients with CHF.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2001-12-30.第四军医大学武警主治医师提高班学员。原工作单位: 武警云南总队医院内一科, 云南 昆明 650000
更新日期/Last Update: 2005-05-01