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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2002年第3期

页码:

241-242

栏目:

临床研究

出版日期:

2002-05-01

文章信息/Info

Title:

Therapetic effect of perindopril on congestive heart failure

作者:

闫爱国;  荣　芳;  陈登国

淄博市中心医院干部病房, 山东 淄博 255000

Author(s):

YAN Ai-guo;  RONG Fang ;  CHEN Deng-guo

Zibo Central Hospital, Zibo, Shandong 255000, China

关键词:

心力衰竭;  充血性;  超声心动描记术;  多普勒;  培哚普利;  神经激素;  血管内皮功能

Keywords:

heart failure;  congestive;  echocardiography;  doppler;  perindopril;  neurohormone;  vascular endothelium

分类号:

R541.61;R972

DOI:

-

文献标识码:

A

摘要:

目的 观察培哚普利(Pe) 对充血性心力衰竭(CHF) 的疗效及其对神经激素、血管内皮功能的作用。方法 对56例CHF 患者口服Pe 4mg/d 6个月疗效进行观察, 并与56例临床特征相匹配的患者对照。结果 治疗组血管紧张素Ⅱ (AngⅡ )、醛固酮(ALD)、内皮素(ET) 和心房钠尿肽(ANP) 显著降低(P<0.01) , 血浆肾素活性(PRA ) 显著升高(P<0.01) , 左室功能显著改善(P<0.05)。结论 Pe 长期口服是治疗CHF的有效药物。

Abstract:

AIM To assess the effects of perindopril on neurohormonal activation,vascular endothelial dysfunction and its clinical efficacy in patient with congestive heart failure(CHF).METHODS 56 patients with CHF treated with oral perindopril (4 mg daily) for 6 months were included in the treatment group,56 patients with matched clinical characteristics were included in the control group.RESULTS:The plasma levels of AngⅡ,ALD,ET,ANP significantly decreased (P<0.01),PRA significantly increased (P<0.01). The function of left ventricle were markedly improved (P<0.05). CONCLUSION Perindopril take a important role in treatment of CHF.

参考文献/References

[1] 陈亚丽,王士昌,赵维江,等.充血性心衰患者血清细胞因子变化及与肾素-血管紧张素系统相关性的研究[J].临床心血管病杂志,2001,17:26-27.

[2] 孙迪安,浦寿月.地高辛治疗慢性心力衰竭的争议[J].中华心血管病杂志,1996,24:153.[3] Drexler H, Kurz S,Jerrish M,et al. Effect of chronic angiotension-converting enzyme inhibition on endothelial function in patients with chronic heart failure[J].Am Heart J,1995,76:13E-18E.

[4] 邓南伟,戚秀卿,罗 明,等.培哚普利对心衰患者神经激素激活及血管内皮功能的临床作用[J].临床心血管病杂志,1999,15:209-213.

备注/Memo

备注/Memo:

收稿日期：2001-03-12.

常用功能

更新日期/Last Update: 2005-05-01