我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

血浆同型半胱氨酸对冠心病患者血管内皮功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第4期
页码:
305-306,309
栏目:
临床研究
出版日期:
2002-07-01

文章信息/Info

Title:
The effect of plasma homocysteine on endothelial secretive function in coronary heart disease patients
作者:
唐梦熊;  黄文增;  张步延;  龚　斐
武汉大学中南医院内四科, 湖北 武汉 430071
Author(s):
TANG Meng-xiong ;  HUANG Wen-zeng ;  ZHANG Bu-yan;  GONG Fei
Fourth Departme t of internal Medicine, Zhongnan Hospital,Wuhan University,Wuhan, Hubei 430071, China
关键词:
冠状动脉疾病;  同型半胱氨酸;  内皮素;  一氧化氮
Keywords:
coronary disease;  homocysteine;  endothelin;  nitric oxide
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨同型半胱氨酸(Hcy) 对冠状动脉粥样硬化患者血管内皮分泌功能的影响及可能机制。方法 采用高效液相色谱法测定57 例冠状动脉粥样硬化患者和40 例健康体检者空腹血浆Hcy 水平, 放射免疫法测定血浆内皮素(ET) , 同时测定血浆一氧化氮(NO )、丙二醛(MDA )、超氧化物歧化酶(SOD) 水平。结果 ①冠心病患者伴或不伴高同型半胱氨酸血症空腹血浆Hcy, ET,MDA 水平均高于健康对照组,NO , SOD 水平则低于健康对照组。②冠心病患者中, 高Hcy 血症组ET 水平略高于非高Hcy 血症组,NO 水平较非高Hcy 血症组低, 两亚组间MDA , SOD 水平无明显差异。结论 高Hcy 血症可促进冠心病患者血浆ET 水平增高,NO 水平降低, 加重血管内皮功能紊乱。本研究不支持Hcy 通过氧化应激抑制损伤人体血管内皮功能的假说。
Abstract:
AIM To study the effect of homocysteine(Hcy) on secretive function of endothelium in coronary hearte disease (CHD).METHODS Plasma Hcy levels of 57 subjects with CHD and 40 healthy subjects were determined by high performance liquid chromatography. Plasma Endothelium(ET) concentration was measured by radioimmunoassay,plasma nitric oxide(NO), malondialdehyde(MDA),superoxide dismutase(SOD) were also measured.RESULTS ①The values of plasma Hcy,ET,MDA in CHD patients were markedly higher than the control group(P<0.01),the levels of NO,SOD were decreased in CHD patients (P<0.01).②Plasma ET of the CHD patients with hyperhomocysteinemia was slightly higher than the CHD patients without hyperhomocysteinemia(P<0.05),and plasma NO was less than the latter group (P<0.05). But no difference occurred in these two groups.CONCLUSION Hyperhomocysteinemia exerts its deleterious effects on endothelial function in CHD patients through impaires the balance of plasma ET and NO. Our dates do not support previous hypothesis that endothelial damage by homocysteine is via oxidative mechanism in humans.

参考文献/References

[1] Arnesen E, Refsum H, Bonaa KH,et al. Serum total homocysteine and coronary heart disease [ J ].Int J Epidemiol,1995,24(4):704-709.

[2] 蒋珍妮,俞 锋.同型半胱氨酸与心血管疾病关系的研究进展[J].心脏杂志,2000,12(3):216-218.

[3] Bellamy MF, Mcdowell IFW, Ramsey MW,et al. Hyperhomocysteinemia after an oral methionine lead acutely impaires endothelial function in healthy adults [ J ].Circulation,1998,98:1848-1852.

[4] Kang SS. Treatment of hyperhomocyst(e)inemia:physiological basis[J].J Nutr,1996,126(4 suppl):1273s-1275s.

[5] Jacoben DN, Getautis VJ, Green R,et al. Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: sex differences and correlation with cobolamin and folate concentrations in healthy subjects[J].Clin chem, 1994,40(6):857-858.

[6] Stamler JS, Osborne JA, Jaraki O,et al. Adverse vascular effects of homocysteine are modulated by endothelium derived relaxing factor and related oxides of nitrogen [J].J Clin Invest,1993,91(1):308-318.

[7] Upchurch GR,Welch GN,Fabian AJ,et al. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase [J].J Biol Chem, 1997, 272 (27): 17012-17017.

[8] Blom HJ,Kleinveld HA,Boers GH,et al. Lipid peroxidation and susceptibility of low-density lipoprotein to in vitro oxidation in hyperhomocysteinemia[J].Eur J Clin Invest,1995,25(3): 149-154.

[9] Ueland PM. Homocysteine species as components of plasma redox thiol status[J].Clin Chem,1995,41(3):340-342.

[10] Gottsater A,Anwaar I,Eriksson KF,et al. Homocysteine is related to neopterin and endothelin in plasma of subjects with disturbed glucose metabolism and reference subjects [J].Angiology,2000,51(6):489-497.

备注/Memo

备注/Memo:
收稿日期：2001-04-26.
更新日期/Last Update: 2002-07-01