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|本期目录/Table of Contents|

心肌缺血/再灌注中心肌细胞凋亡的研究进展(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第4期
页码:
350-352
栏目:
讲座与综述
出版日期:
2002-07-01

文章信息/Info

Title:
-
作者:
李俊峡1;  吕泽平2综述; 贾国良1审校
1.第四军医大学西京医院心血管内科,陕西西安710032;2.南宁市江滨医院神经内科,广西南宁
Author(s):
-
关键词:
缺血/再灌注; 细胞凋亡; 心肌; 发病机制
Keywords:
-
分类号:
R542.22
DOI:
-
文献标识码:
A
摘要:
本文综述了心肌缺血/再灌注中心肌细胞凋亡的证据、诱发因素、相关调控基因、病理生理作用和临床意义。
Abstract:
-

参考文献/References

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[4] Zhao ZQ,Nakamura M,Wang NP,et al. Reperfusion induces myocardial apoptotic cell death[J].Cardiovasc Res,2000,45:651-660.

[5] Saraste A. Apoptosis in human acute myocardial infarction[J].Circulation,1997,95:320-323.

[6] Misao J. Expression of bcl-2 protein, an inhibitor of apoptosis, and bax, an accelerator of apoptosis,in ventricular myocytes of human hearts with myocardial infarction[J].Circulation,1996, 94:1506-1512.

[7] Sharov VG. Increased expression of apoptosis associated p53 protein in cardiocytes of dogs with chronic heart failure[J].Circulation,1995,92(SupplⅠ):525-527.

[8] Von Harsdorf R,Li PF,Diietz R,et al. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis [J].Circulation,1999,99:2934-2941.

[9] Yang BC,Zander DS,Mehta JL,et al. Hypoxia reoxygenation induced apoptosis in cultured adult rat myocytes and the protective effect of platelets and transforming growth factor-beta(1)[J].J Pharmacol Exp Ther,1999,291:733-738.

[ 10 ] Weiland U, Haendeler J, Ihling C,et al. Inhibition of endogenous nitric oxide synthase potentiates ischemia-reperfusion-induced myocardial apoptosis via a caspase-3 dependent pathway[J].Cardiovasc Res,2000,45:671-678.

[11]Kirshenbaum LA. The bcl-2 gene product prevent programmed cell death of ventricular myocytes[J].Circulation,1997,96:1580-1585.

[12]Olivetti G,Quaini F,Sala R,et al. Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving protion of the heart[J].J Mol Cell Cardiol,1996,28:2005-2016.

[13]Sawa Y. Overexpression of bcl-2 gene improves the myocardial tolerance to ischemia reperfustion by preventing DNA fragmentation[J].Circulation,1995,92(SupplⅠ):772-224.

[14] Nakamura M, Wang NP, Zhao ZQ,et al. Preconditioning decreases Bax expression,PMN accumulation and apoptosis in reperfused rat heart[J].Cardiovasc Res,2000,45:661-670.

备注/Memo

备注/Memo:
收稿日期：2001-03-13.
更新日期/Last Update: 2002-07-01