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|本期目录/Table of Contents|

丙种球蛋白治疗病毒性心肌炎的实验研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第5期
页码:
384-386
栏目:
基础研究
出版日期:
2002-09-01

文章信息/Info

Title:
A experimental study ofγ-globulin in the treatment of viral myocarditis
作者:
张 松; 饶邦复
浙江省人民医院心内科,浙江杭州310014
Author(s):
ZHANG Song; RAO Bang-fu
Cardiovascular Department ,Zhejiang Provincial Hospital,Hangzhou,Zhejiang 310014,China
关键词:
心肌炎; 病毒性; 治疗; 丙种球蛋白
Keywords:
myocarditis; viral; therapy; γ-globulin
分类号:
R542.21
DOI:
-
文献标识码:
A
摘要:
目的 探讨丙种球蛋白对病毒性心肌炎(VMC)小鼠的治疗作用。方法 本实验在建立VMC小鼠动物模型的基础上,用丙种球蛋白(GB)进行干预治疗。比较治疗组和对照组小鼠的死亡率及心肌组织病理改变。结果 GB治疗组小鼠死亡率(9%)较生理盐水对照组(48%)明显降低(P<0.05),心肌病变(炎细胞浸润和坏死)也较生理盐水组明显减轻(病变评分P<0.01)。结论 GB对VMC具有治疗作用。
Abstract:
AIM To study the therapeutic effect ofγ-globulin (GB) on viral myocarditis(VMC).METHODS Our experiment studied the treatment of VMC by GB intervention on the basis of establishing murine model of VMC. The death rate and the pathological findings of myocardium in mice of the treatment group were compared with those of the control group.RESULTS The death rate(9%) of the mice in GB intervention group decreased apparently compared with that of the saline group (48%)(P<0.05).CONCLUSION GB had therapeutic effect on VMC.

参考文献/References

[1] Kanda T,Mcmanus JW,Nagai R,et al. Modification of viral myocarditis in mice by interleudin-6[J].Circ Res ,1996, 78(5): 848-856.

[2] 王向宇,吴可贵,林经安.病毒性心肌炎小鼠模型的建立[J].福建医学院学报, 1995,29(3):295-297.

[3] Gauntt CJ,Hihdon AL,Arizpe HM,et al. Epitopes shared between coxsackievirus B3(CVB3) and normal heart tissue contribute to CVB3-induced murine myocarditis[J].Clin Immunol Immunopathol, 1993, 68(2): 129-134.

[4] Drucker NA,Colan SD,Lewis AB,et al.γ-globulin treatment of acute myocarditis in the pediatric population[J].Circulation, 1994,89:252-257.

[5] Takada H,Kishinoto C,Hiraoka Y. Therapy with immunoglobulin suppresses myocarditis in a murine coxsackievirus B3model [J].Circulation, 1995, 92: 1604-1611.

[6] Darville T,Milligan LB,Laffoon KK. Intravenous immunoglobulin inhibits staphylococcal toxin-induced human mononuclear phagocyte tumor necrosis factor alpha production[J].Infect Immun,1997,65(2):366-372.

[7] Groothius JR, Simoes EA,Leuin MJ,et al. Prophylatic administration of respiratory syncytial virus immune globulin to high-risk infants and young children[J]. N Engl J Med,1993,329:1524-1530.

[8] Dalakas MC,Illa I,Bambrosia MJ, et al. A controlled trial of high-dose intravenous immune globulin infusions as treatment for dermatomyositis[J].N Engl J Med, 1993, 329: 1993 -2000.

备注/Memo

备注/Memo:
收稿日期：2001-04-23.
更新日期/Last Update: 2002-09-01