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|本期目录/Table of Contents|

血小板糖蛋白受体ⅠaC807T基因多态性与心肌梗死关系的研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第5期
页码:
387-389, 392
栏目:
临床研究
出版日期:
2002-09-01

文章信息/Info

Title:
A study of the relationship between platelet glycoprotein receptorⅠa C807T gene polyniorphism and myocardial infarction
作者:
朱刚艳; 黄从新; 江 洪; 李建军
武汉大学人民医院心内科,湖北武汉430060
Author(s):
ZHU Gang-yan;  HUANG Cong-xin;  JIANG Hong;  LI Jian-jun
Department of Cardiology,Renmin Hospital of Wuhan University,Whuan,Hubei 430060,China
关键词:
基因; 多态性; 血小板糖蛋白; 心肌梗塞
Keywords:
gene; polymorphism; platelet glycoprotein; myocardial infarction
分类号:
Q513.2;R542.22
DOI:
-
文献标识码:
A
摘要:
目的 检测中国人群血小板糖蛋白(GP)受体Ⅰa C807T基因多态性,以明确中国人群血小板GPⅠa C807T的基因型,并探讨其多态性与心肌梗死(MI)之间的关系。方法 提取人基因组DNA,应用引物序列特异性多聚酶链反应(SSP-PCR)技术对小于60岁的MI患者72例和对照者70例分别进行血小板GP受体Ⅰa C807T基因多态性检测。结果 中国人群血小板GPⅠa C807T具3种基因型(TC,CC,TT),MI患者T等位基因携带频率明显高于对照组(64%vs47%,P<0.05)。结论:年龄小于60岁的MI患者T等位基因携带频率高,血小板膜GPⅠa受体的遗传性差异在MI发病中可能具有重要作用。
Abstract:
AIM To detect the platelet glycoprotein(GP) receptorⅠa C807T gene polymorphism of Chinese,and to investigate the possible relationship between myocardial infarction(MI) and platelet GPⅠa C807T gene polymorphism. METHODS Leukocyte DNA was isolated from whole blood using standard procedures. Platelet GP receptorⅠa C807T gene polymorphism was detected by sequence specific primer(SSP)-polymerase chain reaction (PCR) method in 72 patients with MI(<60 years old) and 70 control subjects.RESULTS The platelet GPⅠa of Chinese has three gene types(TC,CC,TT). The frequency of T allele was higher in patients with MI than that in control subjects(64%vs47%,P<0.05)。CONCLUSION The frequency of T allele was significantly increased in patients with MI(<60 years old). Inherited platelet GPⅠa variations might play an important role in MI.

参考文献/References

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[3] Weiss EJ,Bray PF,Tayback M,et al. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis[J].N Engl J Med,1996,334(17):1090 -1094.

[4] 陆 林,于金德,乐 玮.血小板受体糖蛋白Ⅲa基因与心肌梗塞关系的研究[J].中华心血管病杂志,1999,27(2):111-112.

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[7] Moshfegh K,Wuillemin WA,Redondo M,et al. Association of two silent polymorphisms of platelet glycoproteinⅠa/Ⅱa receptor with risk of myocardial infarction:a case-control study [J].Lancet,1999,353(9150):351-354.

备注/Memo

备注/Memo:
收稿日期：2001-05-24.基金项目:湖北省“九五”攻关项目资助 (No.962101101)
更新日期/Last Update: 2002-09-01