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胺碘酮治疗心房颤动临床疗效的观察(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第5期
页码:
393-395
栏目:
临床研究
出版日期:
2002-09-01

文章信息/Info

Title:
Efficacy of amiodarone for the termination of atrial fibrillation
作者:
何 勇; 郑强荪; 高敏娟; 杨欣国; 史俊忠; 吴学勤
第四军医大学唐都医院心脏内科,陕西西安710038
Author(s):
HE Yong; ZHENG Qiang-sun; GAO Min-juan; YANG Xin-guo; SHI Jun-zhong; WU Xue-qin
Department of Cardiology,Tangdu Hospital,Fourth Military Medical University,Xi' an, Shaanxi 710038,China
关键词:
心房颤动; 胺碘酮; 治疗
Keywords:
atrial fibrillation; Amiodarone; treatment
分类号:
R541.7;R972.2
DOI:
-
文献标识码:
A
摘要:
目的 探讨胺碘酮治疗心房颤动的效果。方法 依据房颤的频度及持续时间分为阵发性房颤(间歇发作)30例、持续性房颤20例及慢性房颤14例。结果 使用胺碘酮治疗8个月后总有效率分别为87%,70%,64%,治疗12个月后总有效率分别为80%、62%及54%;疗效与左房大小、房颤持续时间等因素有关。服用药物期间,除3例出现甲低而停药;1例因严重腹泻发生扭转性室速(Tdp)外,其余病例无严重不良反应。结论 胺碘酮治疗房颤安全有效,可以作为首选药物。
Abstract:
AIM To observe about the effect of amiodarone for the termination of atrial fibrillation (AF).METHODS According to the frequency and lasting time of the atrial fibrillation, it can be divided into three groups,one group is paroxysmal AF (intermission episode),another is persistent AF,the third group is chronic AF.RESULTS After 8 months treatment of amiodraone ,the utility of three groups is 87%,70%,64% respectively. The utility is 80%,62%,54% after 12 months treatment of amiodraone respectively. It has a better effect of amiodarone termination of paroxysmal AF. The effect is related to the size of left atrium, the lasting time of AF. During taking the medicine, there is no severe side effect,expect 3 patients withdrawal because of hypothyroidism,1 patient occurred Tdp because of severe diarrhea.CONCLUSION Amiodarone therapy AF is safe, and it can be the first choice.

参考文献/References

[1] 马长生,刘兴鹏,颜红兵,等.经导管射频消融治疗局灶性心房颤动[J].中国心脏起搏与心电生理杂志,1999,13:197-200.

[2] Edvardsson N. Comparison of classⅠand classⅢaction in atrial fibrillation[J].Eur Heart J,1993,14(SupplⅡ):62-67.

[3] George EK, Nikos EI, Marios CS,et al.Efficacy of amiodarone for the termination of persistent atrial fibrillation[J] .Am J Cardial,1999,83:58-65.

[4] Sicouris S, Moro S, Litovsky S,et al. Chronic amiodarone reduces transmural dispersion of depolarization in the canine heart [J].J Cardiovasc Electrophysiol,1997,8:1269-1278.

[5] Nishimura M, Follmer CH, Cigan AL,et al. Amiodarone blocks Ca2+current in guinea pig myocytes[J]. Circulation, 1986,74(supplⅡ):169(676).

[6] Follmer CH, Aomine M, Yeh JZ,et al.Amiodarone-induced block of sodium current in isolated cardiac cell[J].J Pharamacol Exp Ther,1987,243:187-195.

备注/Memo

备注/Memo:
收稿日期：2001-06-01.
更新日期/Last Update: 2002-09-01