我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

老年高血压病患者红细胞变形能力与LPO、血浆SC5b-9水平的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第5期
页码:
415-416, 419
栏目:
临床研究
出版日期:
2002-09-01

文章信息/Info

Title:
Changes of erythrocyte deformability,erythrocyte membrane lipidperoxide and plasma SC5b-9in aged patients with hypertension
作者:
龚 侃;  杨美英;  任秋萍;  陆 伟;  尹红金
济南军区青岛第一疗养院,山东青岛266071
Author(s):
GONG Kan; YANG Mei-ying; REN Qiu-ping; LU Wei; YIN Hong-jin
Qingdao No.1 Sanatorium of Jinan Military Region, Qingdao, Shandong 266071,China
关键词:
老年; 高血压; 红细胞变形能力; 红细胞膜; 脂质过氧化物; 补体
Keywords:
aged;  hypertension;  erythrocyte deformability;  erythrocyt emembrane; lipid peroxide; complement
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨老年高血压病患者红细胞变形能力(ED)变化与红细胞膜脂质过氧化物(LPO)、血浆补体激活片段(SC5b-9)浓度的关系。方法 采用DXC-300A型核孔膜红细胞变形能力测定仪,硫代巴比妥酸比色法和ELISA法,检测了104例老年高血压病患者红细胞滤过指数(EFI)、红细胞LPO含量和SC5b-9浓度的变化,并与对照组进行比较。结果 老年高血压病患者EFI,LPO,SC5b-9明显增高,与对照组的差异非常显著(P<0.01),且上述各项指标随病情严重程度增加而增高(P<0.01)。EFI与LPO,SC5b-9呈正相关(r=0.673,0.726;P< 0.01)。结论 老年高血压病患者ED降低与红细胞LPO和血浆SC5b-9增高有密切关系。
Abstract:
AIM To explore the changes of the erythrocyte deformability(ED),eryt hrocyte membrane lipid peroxide(LPO) and plasma complement activation composition(SC5b-9) in aged patients with hypertension. METHODS By using erythrocyte deformability apparatus, thiobarturicacid method and ELISA methods,the erythrocyte filtration index( EFI),LPO and SC5b-9 were measured in 104 aged patients with hypertension and 56 controls. RESULTS The EFI,LPO, SC5b-9 were significantly higher in aged patients with hypertension than those in controls (P<0. 01),Remarkable differences of these parameters were found among patients with three stages(P<0.01) and the most obvious increase of the changes was found in stageⅢ. In aged patients with hypertension the EFI was positively correlated with LPO and SC5b-9 (r=0.673,0.726;P< 0.01). CONCLUSION The decrease of ED in aged patients with hypertension was related to the increase of erythrocyte membrane LPO and plasma SC5b-9 concentration.

参考文献/References

[1] Hasegawa S,Rodgers GP,Shio H, et al.Impaired deformability of Heiz body forming red cells[J]. Biorheology, 1993, 30(3-4): 275-281.

[2] Vakeva A,Morgon BP,Tikkannen I, et al. Time course of complement activation and inhibitor expression after ischemic injury of rat myocardium[J].Am J Pathol,1994,144(6): 1357 -1360.

[3] 王丽君,李 晖,谭润鸾.冠心病患者红细胞变形能力与脂质过氧化损伤及血浆SC5b-9浓度的关系[J].齐鲁医学杂志,1999,14(4):241-243.

[4] Capari P,Bozzi A, Malorni W, et al. Junctional site of erythrocyte skeletal proteins are specific targets of tert-butylhydroperoxide oxidative demage[J].Chem Biol Interact,1995,94(3):243-248.

[5] Amsterdam EA,Stahl GL,Pan HL,et al.Limitation of reperfusion injury by a monoclonal antibody to C5a during myocardial infarction in pigs[J].Am J Physiol,1995,268(1pt2):H448-453.

[6] Hansch GH. The complement attack phase: control of lysis and nonlethal effacts of C5b-9[J].Immunopharmacol,1992,24:107-112.

备注/Memo

备注/Memo:
收稿日期：2002-04-29.
更新日期/Last Update: 2002-09-01