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κ-阿片受体在抑制心肌肥厚中的作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第6期
页码:
465-468
栏目:
实验研究
出版日期:
2002-11-01

文章信息/Info

Title:
The inhibitory effects ofκ-opioid receptor on cardiac hypertrophy
作者:
裴建明1;  陈 迈2;  毕 辉1;  王跃民1;  朱运龙1
第四军医大学:1.基础部生理学教研室, 2.西京医院心内科,陕西西安710032
Author(s):
PEI Jian-ming1;  CHEN Mai2;  BI Hui1;  WANG Yue-min1;  ZHU Yun-long1
1.Department of Physiology; 2.Department of Cardiology, Fourth Military Medical University, Xi' an 710032, China
关键词:
受体; κ-阿片; U50; 488H; 心肌肥厚; 细胞培养
Keywords:
receptor; κ-opioid;  U50;  488H;  cardiac hypertrophy;  cell culture
分类号:
R331.3
DOI:
-
文献标识码:
A
摘要:
目的与方法 在儿茶酚胺诱导的大鼠心肌肥厚及培养的心肌细胞中,观察κ-阿片受体选择性激动剂U50,488H对心肌肥厚及心肌细胞生长的作用。结果大鼠静脉注射异丙肾上腺素2周(3 mg·kg-1·d-1)发生心肌肥厚,表现为心脏重量指数明显增加,光镜和电镜显示明确的肥厚性组织病理学改变。U50,488H可明显改善这些异常改变。且对去甲肾上腺素引起的促心肌细胞生长具有明显的抑制作用。结论κ-阿片受体在抑制心肌细胞的生长和心肌肥厚的发生发展中具有重要的负性调节作用。
Abstract:
AIM and METHODS To investigate the effects of U50,488H (a selectiveκ-opioid receptor agonist) on cardiac hypertrophy and cardiac cells growth induced by catecholamine.RESULTS The cardiac hypertrophy was developed following isoproterenol ((3 mg·kg-1·d-1)intravenously for 2 weeks. The cardiac weight index increased significantly with the hypertrophic alteration in light micrographs of cardiac tissue and transmission electron micrographs of myocardial ultrastructure. Administered U50,488Hsignificantly attenuated these abnormal changes and markedly inhibited the cardiac cells growth stimulated by norepinephrine.CONCLUSIONκ-opioid peptide attenuates the cardiac hypertrophy, andκ-opioid receptor plays an important negatively role in the development of cardiac hyperytrophy and cell growth.

参考文献/References

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[9] Pei JM, Wang YM, Chen M,et al. Signaling pathway mediated by κ-opioid receptor is impaired in cardiac hypertrophy[J].Acta Pharmacologica Sinica, 2001,22(10):865-960.

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备注/Memo

备注/Memo:
收稿日期：2002-03-25.基金项目：军队医药卫生“十五”课题基金 (01M129)及第四军医大学创新工程重点项目基金 (CX01F001)
更新日期/Last Update: 2002-11-01