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卡维地洛与美多心安治疗稳定型心绞痛的临床疗效比较(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第6期
页码:
488-490
栏目:
临床研究
出版日期:
2002-11-01

文章信息/Info

Title:
Efficacy of carvedilol compared with metoprolol in stable angina
作者:
张利华1;  薛玉生1;  赵季红1;  刘 军1;  郑强荪1;  肖俊平2;  柳 荫1;  谢伯雅1
第四军医大学唐都医院:1.心内科,2.心电图室, 陕西西安 710038
Author(s):
ZHANG Li-hua; XUE Yu-sheng; ZHAO Ji-hong; LIU Jun; ZHENG Qiang-sun; XIAO Jun-ping; LIU Yin; XIE Bo-ya
Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038,China
关键词:
β-受体阻滞剂; 卡维地洛; 美多心安; 心绞痛; 不稳定型; 治疗
Keywords:
β-adrenergic receptor blocker;  carvedilol;  metoprilol;  angina; stable;  treatment
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 比较卡维地洛与美多心安治疗稳定型心绞痛(SA)的临床疗效。方法 将SA患者随机分为卡维地洛治疗组(n=80)和美多心安治疗组(n=76),观察用药6周后治疗有效率以及心肌耗氧量(RPP)和两组患者治疗期间的心血管危险事件发生率。结果 ①卡维地洛组临床治疗总有效率明显高于美多心安组(92%vs80%,P<0.05)。②卡维地洛组RPP明显减少,用药前后分别为(1491±225)kPa·min-1和(1232±211) kPa·min-1(P<0.05 );美多心安组用药前后分别为(1500±270) kPa·min-1和(1499±115) kPa·min-1,无显著差异(P>0.05)。结论:卡维地洛临床疗效明显优于美多心安。
Abstract:
AIM To evaluate the clinical effect of differentβ-blockades in patients of stable angina (SA).METHODS SA patients were randomly divided into two groups, one is the treatment goup(n=80) which was treated with carvedilol, the other is the control group(n=76) which was treated with metoprolol, and the clinical effective treatment, the rate pressure product (RPP) were observed after treated six weeks. RESULTS ①The clinical effectiveness of the treatment group was significantly higher than the control group (92%vs80%P<0.05).②RPP of the treatment group was significantly decreased than that before treated (1491±225) kPa·min-1vs (1232±211) kPa·min-1(P<0.05), But it was no significant difference in the control group (1500±270) kPa·min-1vs(1499±115) kPa·min-1(P>0.05).③The cardiovascular episodes of the treatment group were significantly decreased than that of the control group(P<0.05). CONCLUSION The clinical effect of carvedilol was much better than that of metoprilol.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2002-02-28.
更新日期/Last Update: 2002-11-01