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|本期目录/Table of Contents|

血管紧张素转换酶抑制剂治疗充血性心力衰竭的剂量问题(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第6期
页码:
543-545
栏目:
综述
出版日期:
2002-11-01

文章信息/Info

Title:
-
作者:
武育蓉 综述; 陈树宝 审校
上海第二医科大学附属新华医院上海儿童医学中心心内科,上海200127
Author(s):
-
关键词:
血管紧张素转换酶抑制剂; 心力衰竭; 充血性; 剂量
Keywords:
-
分类号:
R541.61
DOI:
-
文献标识码:
A
摘要:
血管紧张素转换酶抑制剂(ACEI)是治疗充血性心力衰竭的基础药物,但是临床所应用的剂量却远低于大规模临床实验所推荐的剂量。多数研究显示高剂量ACEI能更有效抑制肾素血管紧张素醛固酮系统,改善血流动力学和神经内分泌异常,减轻心衰症状,改善预后,而且未发生难以控制的严重不良反应。
Abstract:
-

参考文献/References

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[2] Jorde UP, Ennezat PV,Lisker BA. Maximally recommended doses of angiotensin converting enzyme inhibitors do not completely prevent ACE-mediated formation of angiotensinⅡin chronic heart failure[J].Circulation,2000,101:844-846.

[3] Rocca HP, Weilenmann D,Kiowski W.Within-patient comparison of effects of different dosages of enalapril on functional capacity and neurohormonal levels in patients with chronic heart failure[J].Am Heart J,1999,138:654-662

[4] Gullestad L,Aukrust P, Ueland T.Effects of high-versus low-dose angiotensin converting enzyme inhibitor on cytokine levels in chronic heart failure[J].J Am Coll Cardiol,1999,34:2061-2067..

[5] Clement DL,De Buyxere M,Tomas M,et al. Long-term effects of clinical outcome with low and high dose in the captopril in heart insufficient patients study[J].Acta Cardiol, 2000, 55(1):1-7.

[6] Pacher M, Poole-Wilson PA, Armstrong PW.Comparative effects of low and high doses of the angiotensin converting enzyme inhibitor,lisinopril,on mortality in chronic heart failure [J].Circulation,1999,100:2312-2318.

[7] Massie MB,Armstrong PW,Clcland JGF. Tolerance of highversus low-dose angiotensin converting enzyme inhibitor in chronic heart failure[J].Arch Intern Med,2001,161:165-171

备注/Memo

备注/Memo:
收稿日期：2002-03-25.
更新日期/Last Update: 2002-11-01