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存活心肌31P-MR波谱的研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第1期
页码:
49-51
栏目:
影像学
出版日期:
2003-01-01

文章信息/Info

Title:
Study in human viable myocardium by 31P magnetic resonance spectroscopy
作者:
赵海涛1; 陆军1; 张卓立1; 黄志兰1; 李俊峡2; 高峰3; 张胜利3
第四军医大学西京医院:1.放射科2.心内科3.心外科,陕西 西安 710032
Author(s):
ZHAO Hai-tao1;  LU Jun1;  ZHANG Zhuo-li1;  HUANG Zhi-lan1;  LIJun-xia2;  GAO Feng3;  ZHANG Sheng-li3
Department of radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China
关键词:
存活心肌; 磁共振成像; 磁共振频谱; 高能磷酸盐
Keywords:
viable myocardium;  magnetic resonance imaging;  magnetic resonance spectroscopy;  high-energyphosphates
分类号:
R445.2
DOI:
-
文献标识码:
A
摘要:
目的:探讨存活心肌高能磷酸盐变化。方法:用心脏电影磁共振成像(Cine-MRI)和2D-CSI31P磁共振频谱(MRS)研究17例急性前壁心肌梗死6h内成功再灌注患者6±2d后的磷酸肌酸(PCr)与ATP的比值;其中16例患者急性前壁心肌梗死后39±8d再次做31P-MRS及心脏Cine-MRI检查。7位健康自愿者作对照组参加研究。结果:患者心功能明显恢复心肌阶段(存活心肌)PCr/ATP比值,早期为1.53±0.16,晚期为1.57±0.10,早期与晚期比较,早期与正常对照组(1.59±0.13)比较均P>0.05。结论:国人存活心肌状态下心肌PCr/ATP比值在正常范围内。
Abstract:
AIM: To investigate whether alterations in cardiac high-energy phosphates occur in postischemic viable myocardium. METHODS: We studied 17 patients with a first anterior myocardial infarction (MI) who under went successful reperfusion within 6h of onset of chest pain. These patients underwent 31P MRS and cine-MRI after MI 6±2 days for measurement of left ventricular regional function and relative high energyp hosphate metabolisms. 16 patientsunderwent these cond3 1P-MRS and Cine-MRI after MI 39±8 days. Seven Volunteers served as control subjects. RESULTS: Cine-MRI demonstrated significant recovery of regional function where no difference was found between early cardiac phosphocreatine PCr/ATP ratiosin patients and control subjects (1.53±0.16vs1.59±0.13,P>0.05) or between early and late PCr/ATP ratiosin patients (1.53±0.16vs1.57±0.10,P>0.05). CONCLUSION: Relative cardiac high energy phosphates are not depleted in viable myocardium.

参考文献/References

[1] 赵海涛, 陆军, 张卓立, 等. 在体心脏31P磁共振波谱化学位移成像技术 [J] . 心脏杂志, 2002, 14(1)80-82.

[2] Eduard R, Holman MA, Vincent G, et al. Detection and quantification of dysfunctional myocardium by magnetic resonanceimaging [J] . Circulation, 1997, 95(4):924-931.

[3] Rehr RB, Taturn JL, Hirsh JI, et al. Reperfused viable and reperfused-infarcted myocardium: differentiation with in vivo 31P-MR spectroscopy [J] . Radiology, 1989, 172(1):53-58.

[4] Baer FM, Erdmann E. Assessment of myocardial viability [J] .Thorac cardiovascular surgery, 1998, 46(2):264-269.

[5] Kienlin M, Behr W. Three-dimensional 31P magnetic resonance spectroscopic imaging of regional high-energy phosphate metabolism in injured rat heart [J] . Magn Resen Med, 1998, 39(4):731-741.

[6] Meininger M, Lanschutz W, Beer M, et al. Concentrations of human cardiac phosphorus metabolites determined by SLOOP31 PNMR spectroscopy [J] . Magn Reson Med, 1999, 41(4):657-663.

[7] Kienlin M, Beer M, Greiser A, et al. Advances in human cardic 31P-MR spectroscopy: SLOOP and cliniapplications [J] . Magn Reson Imaging, 2001, 13(3):521-527.

[8] Przyklenk K, Kloner RA. Superoxide dismutase plus catalane improve contractile function in the canine model of the stunned myocardium [J] . Circ Res, 1986, 58(1):148-156.

[9] Beer M, Sandstede J, Landschutz W, et al. Alteres energy metabolism after myocardial infarction assessed by31P-MR spectroscopy in humans [J] , Eur Radiol, 2000, 10(7):1323-1328

备注/Memo

备注/Memo:
收稿日期：2002-03-07.
更新日期/Last Update: 2003-01-01