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组织型纤溶酶原激活物及其抑制物-1与血管成形术后再狭窄(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第1期
页码:
70-72
栏目:
综述
出版日期:
2003-01-01

文章信息/Info

Title:
Effects of t-PA and PAI-1 on post angioplastic restenos
作者:
周宁1; 王丽先1; 吕安林2; 贾国良2
1.陕西省第二人民医院,陕西 西安 710005;2.第四军医大学西京医院心血管内科,陕西 西安 710032
Author(s):
ZHOU Ning1;  WANG Li-xian1;  LU An-lin2;  JIA Guo-liang2
1.Department of cardiology, Shaanxi Province 2nd Hospital, Xi'an, Shaanxi 710005; 2.Dpeartment of Cardiology, Xijing, Hospital, Xi'an, Shaanxi 710032, China
关键词:
纤维蛋白溶解活性; 血管成形术; 经腔; 经皮冠状动脉; 再狭窄
Keywords:
fibrinolysis activities;  angioplasty;  transluminal;  percutaneous coronary artery
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
组织型纤溶酶原激活物(t-PA)和纤溶酶原激活物抑制剂-1(PAI-1)参与附壁血栓形成、细胞外基质(ECM)清除和血管平滑肌细胞(VSMC)迁移和增殖的调节,与血管成形术后再狭窄(RS)的关系密切。
Abstract:
It is widely believed that the development of post angioplastic restenosis (RS) is related to submural thrombosis, migration and proliferation of vascular smooth muscle cells (VSMC) and extra deposition of extracellular matrix (ECM). Tissue-type plasminogen activator and plasminogen activator inhibitor-1,through playing significant modulating roles in submural thromburalthrombosis deposition of ECM and migrating and proliferating of VSMC, are closely related with RS.

参考文献/References

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[7] Mussoni L, Banfi C, Sironi L, et al. Fluvastatin inhibits basal ands timulated plasminogen activator inhibitor 1, but induces tissue type plasminogen activator in cultured human endothelial cells [J] .Thromb Haemost, 2000, 84(1):59.

[8] Ishiwata S, Tukuda T, Nakanishi T, et al. Post angioplastic restenosis: platelet activation and the coagulation-fibrinolysis system as possible factors in the pathogenesis of restenosis [J] . Am Heart J, 1997, 133(4):387.

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[10] Kanamasa K, Ogawa I, Hayashi T, et al. Prevention of coronary arterial renarrowing by continuous 3-day in fusion of tissue plasminogen activator after successful percutaneous transluminal coronary angioplasty: a randomed, double-blind, placebo-controlled study [J] . Angiology, 2000, 51(5):367.

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[13] Xiaoli M, Wenying H, Mingpeng S. Effects and mechanism of tissue-type plasminogen activator and plasminogen activator inhibitor on vascular smooth muscle cell proliferation [J] . Int J Cardiol, 1998, 66(Suppl1):S57.

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备注/Memo

备注/Memo:
收稿日期：2001-05-25.
更新日期/Last Update: 2003-01-01