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养阴通脑颗粒对犬血压和心率影响的实验研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第2期
页码:
115-117,120
栏目:
实验研究
出版日期:
2003-03-01

文章信息/Info

Title:
The experimental study of effects about yangintongnao particle on mean blood pressure and heart rate in anesthetized dog
作者:
朱萧玲1; 陈绍洋1; 熊利泽1; 朱肖星2; 梅其炳2; 王跃民3
第四军医大学:1.西京医院麻醉科,2.基础部药理学教研室,3.生理学教研室,陕西 西安 710032
Author(s):
ZHU Xiao-ling1; CHEN Shao-yang1; XIONG Li-ze1; ZHU Xiao-xing2; MEI Qi-bing2; WANG Yao min3
1.Department of Anesthesiology,Xi jing Hospital, 2.Department of Pharmacology,3. Department of Physiology,Faculty of Preclinical Medicine,Fourth Military Medical University, Xi'an,Shaanxi 710032,China)
关键词:
养阴通脑颗粒; 维脑路通; 麻醉犬; 胃饲; 平均血压; 心率
Keywords:
Yangyintongnao particle; weinaolutong pian; anaesthtized dog; administered with gastrogavage;  mean blood pressure; Heart rate.
分类号:
R286
DOI:
-
文献标识码:
A
摘要:
目的:观察养阴通脑颗粒对麻醉犬平均血压和心率的影响。方法:将29只犬随机分为5组,养阴通脑颗粒大 剂量组,中剂量组和小剂量组,用维脑路通作阳性药对照组,空白对照组给等量生理盐水,养阴通脑颗粒、维脑路通 和生理盐水均通过胃管灌入犬胃中。股动脉插管经晶体压力传感器测量主动脉平均血压,心率从心电图的R-R间 期测算。结果:养阴通脑颗粒对平均血压和心率有轻度降低作用,维脑路通对平均血压有轻度升高作用,也有减慢 心率的作用,两种药对血压和心率的影响都无显著意义。结论:养阴通脑颗粒对平均血压和心率无明显影响。表明 其适合于作为缺血性脑血管疾病的治疗用药。
Abstract:
AIM:The chief purpose of the present study was to assess the effect of yangyintongnao particle on mean blood pressure and heart rate in anaesthetized dog.MEHTODS:29 dogs were randomly allocated to five groups.In control group,physiological solution was administered with gastrogavage,In other four groups,a large dose of yangyintongnao particle(2g/kg),a middle dose of yangyintongnao particle(1g/kg),a small dose of yangyintongnao particle(0.5g/kg) and weinaolutong pian were administered with gastrogavage respectively. Aortic mean blood pressure via a piezometric transducer was measured by femoral artery intubation. heart rate was obtained from R-R intervals of electrocardiogram. RESULTS: Yangyintongnao particle reduced slightlymean blood pressure and heart rate, weinaolutong raised lightly blood pressure and slow heart rate, their effect were slight, changes of heart rate and mean blood pressure had no significant. CONCLUSION: Yangyintongnao particle did not cause obviously changes of mean blood pressure and heart rate. The authors have provided good evidence supporting therapeutic effect of this particle against cerebral ischemia.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2002-3-29.
更新日期/Last Update: 2003-03-01