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|本期目录/Table of Contents|

老年心力衰竭患者血浆可溶性TRAIL和受体DR5水平的变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第2期
页码:
118-120
栏目:
临床研究
出版日期:
2003-03-01

文章信息/Info

Title:
Changes in the plasma soluble TRAIL and DR5 in elderly patients with congestive heart failur
作者:
洪燕1; 李源2; 王晓明2; 李影娜3; 欧阳为明3; 金伯泉3
1.武警江西总队医院,江西南昌330001;第四军医大学:2.西京医院老年病科,3.免疫学教研室,陕西 西安 710032
Author(s):
HONG Yan1; LI Yuan2; WANG Xiao-ming2; LI Ying-na3; OU YANG Wei-ming3; JIN Bai quan3
1.Department of Geriatrics,Jiang xi Provincial Corps Hospital,Chinese People's Armed Police forces,Nanchang,Jiang xi 330001,China;2.Department of geriatrics,Xi jing Hospital,Fourth Military Medical University,Xi'an,Shaanxi 710032,China
关键词:
心力衰竭; 充血性; 凋亡; 酶联免疫吸附法; TNF相关的凋亡诱导配体; 死亡受体
Keywords:
heart failure; congestive; elderly; sandwich enzyme-linked immunosorbent assay;  tumor necrosis factor-related apoptosis-inducing ligand; death recepter5
分类号:
R541.61
DOI:
-
文献标识码:
A
摘要:
目的:观察老年充血性心力衰竭(CHF)患者血浆可溶性TNF相关的凋亡诱导配体(sTRAIL)、死亡受体 (sDR5)水平与心功能状态的关系。方法:用酶联免疫吸附法(ELISA)检测41例老年CHF患者和20例健康老年人 (对照组)血浆sTRAIL和sDR5水平,用多普勒超声心动图测定CHF患者左室射血分数(LVEF)。结果:①CHF 患者血浆sTRAIL水平较健康对照组升高(1.45±0.52ng·mL-1vs0.93±0.12ng·mL-1,P>0.05);CHF患者 血浆sDR5水平(41±8pg·mL-1)较对照组(<6pg·mL-1)明显升高,且随心功能损害程度加重而升高,心功能 Ⅳ级者显著高于Ⅱ,Ⅲ级(P<0.05,P<0.01)。②LVEF和sDR5水平呈显著的负相关(r=-0.52,P<0.01)③高 血压心脏病CHF患者血浆sDR5水平明显高于其它病因CHF患者。结论:血浆sDR5水平可能是反映老年CHF 心功能和评价心肌细胞凋亡状态有价值的指标之一。
Abstract:
AIM:To investigate the plasma level of soluble TRAIL and soluble DR5 in the elderly patients with congestive heart failure(CHF).METHODS:The levels of the plasmas TRAIL and sDR5 were determined by enzyme-linked immunosorbent assay(ELISA) in 41 elderly CHF cases and 20 elderly health cases as the control.Left ventricular ejection fraction(LVEF) was measured by colour Dopper echocardiography.RESULTS:①The levels of sTRAIL showed no significant difference between the CHF groups and the control group (1.45±0.52ng·mL-1and 0.93±0.12ng·mL-1,P>0.05);the levels of sDR5 of CHF groups(41±8pg·mL-1) were significantly higher than those of the control group (<6pg·mL-1) and the level of sDR5 increased significantly with the decrease of the cardical function.The plasma level of sDR5 in elderly patients of ClassⅣ were higher than those of ClassesⅡ andⅢ(P<0.05andP<0.01, respectively).② The plasma levels of sDR5 were negatively correlated to LVEF(r=-0.52,P< 0.01).③The levels of sDR5 were significantly higher in the cases with hypertensive heart disease.than in anyother CHF cases due to other factors.CONCLUSION:The determination of sTRAIL and sDR5 may serve as a useful tool for the evaluation of the cardiac function and of the myocardial cell apoptosis.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2002-11-18.
更新日期/Last Update: 2003-03-01