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胚胎干细胞及其心肌细胞定向分化研究进展(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第2期
页码:
159-162,164
栏目:
综述
出版日期:
2003-03-01

文章信息/Info

Title:
Progress in the research of embryonic stem cells and differentiating into cardiomyocyte
作者:
康新勤1; 臧伟进2; 宋土生1; 臧益民3
西安交通大学医学院:1.生物学教研室,2.心血管生理药理研究室,陕西 西安 710061; 3.第四军医大学生理学教研室,陕西 西安 710032
Author(s):
KANG Xin-qin1; ZANG Wei-jin2; SONG Tu-sheng2; ZANG Yi-min3
1.Department of biology,2.Division of Cardiovascular Physiology and Pharmacology,School of Medicine, Xi'an Jiao tong University, Xi'an, Shaanxi 710061,China; 3.Department of Physiology,Fourth Military Medical University,Xi'an,Shaanxi710032,China
关键词:
胚胎干细胞; 心肌细胞; 生物学特性; 细胞培养; 分化
Keywords:
embryonic stem cell;  cardiomyocytes;  biological characteristic;  cell culture differentiation
分类号:
Q254
DOI:
-
文献标识码:
A
摘要:
近年来,胚胎干细胞已成为生命科学研究的热点之一。作者在回顾胚胎干细胞的生物学特性、获取和培养方 法的基础上,着重综述在胚胎干细胞分化为心肌细胞后,心肌细胞特异性基因表达的变化、电生理特征、离子通道 出现、形态学特征和治疗心肌梗死实验的初步结果。
Abstract:
AIM:Embryonic stem cells became one of the highlights of the life science research.On the basis of reviewing the biologic characteristics,deriving and culture method of embryonic stem cells,the article emphases on the cardio-specific genes express,electrophysiology and ion channel emerge and the morphological characteristics after the differentiation into cardiomyocytes as well as the primaryresults in the therapy of myocardial infarction

参考文献/References

[1]Reabinoff BE,Pera MF,Fong CY,et al.Embryonic stem cell lines from human blastcysts: Somatic differentiation in vitro [J]. Nat Biotechnol,2000,18(4):399-404.

[2] Svendsen CN, Smith AG. New prospects for human stem cell therapy in the nervous system [J]. TINS, 1999,22(8):359-363.

[3] Eiges R, Schuldiner M, Drukker M, et al. Establishment of human embryonic stem cell- transfected clones carrying a marker for undifferentiated cells [J]. Curr biol,2001,11:514-518.

[4] Reubinof BE, Pera MF, Fong CY, et al.Embryonic stem cell lines from human blastocysts:somatic differentiation in vitro[J].Nat biotechnol,2000,18:399-404.

[5]Xu C,Inokuma MS,Denham J,et al.Feeder-free growth of undifferentiated human embryonic stem cells [J]. Nat Biotechnol , 2001, 19:971-974.

[6] Paquin J, Danalache BA, Jankowski M,et al.Oxytocininduces differentiation of P19 embryonic stem cells to cardiomyocytes [J].Proc Natl Acad Sci USA,2002,99(14):9550-9555.

[7] Schudiner M, Yanuka O, Joseph I, et al. Effect of eight growth factorson the differentiation of cells derived from human embryonic stem cells [J].Proc Natl Acad Sci USA,2000,97(21) : 11307-11312.

[8] Jonathan S,Christine P,James A,et al. Surface antigens of human embryonic stem cells: changes upon differentiation in culture [J].J Anat,2002,200:249-258.

[9] BremerS, Van dooren M, ParellaM, et al. Effect of embryotoxic chemicals on the in vitro differentiation of genetically embryonic stem cell into cardiac cells [J].Toxicol In Vitro,1999,13:645-650.

[10]Zur NI,Nieden LI,Ruf G,et al Molecular marks in embryonic stem cell[J].Toxicol In Vitro,2001,15:455-461.

[11]Kehat I, Kengagin-Karsenti D, Snir M, et al. Human embryonic stem cell can differentiate into myocytes with structural and functional properties of cardiomyocytes [J]. JClin Invest,2001,108(3):407-414.

[12] Yang HT,Tweedie D,Wang SU,et al.Cardiac ryanodine receptor(RyR2) regulates the spontantaneous rate of contraction of cardiomyocytes differentiated from embryonic stem cells [J]. Circulation, 2001, 104 (17,SuppleII):Ⅱ-194(929Abstr).

[13]Hoganblm WM. Out of Eden,stem and their niches [J].Science,2000,287:142-130.

[14]Min JY,Yang YK,Converse KL,et al.Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats [J]. J Appl Physiol,2002,92(1):288-296.

[15]张航向,李源,臧益民.干细胞移植与心血管疾病[J].心脏杂志,2002,14(6):524-526.

[16] Kaufman DS,Thomson JA.Human ES cells-haematopoiesis and transplantation strategies [J].J Anat,2002,200:243-248.

备注/Memo

备注/Memo:
收稿日期：2002-2-28.
更新日期/Last Update: 2003-03-01