我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

充血性心力衰竭患者尿液水通道蛋白-2的临床检测(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第3期
页码:
239-240,242
栏目:
临床研究
出版日期:
2003-05-01

文章信息/Info

Title:
Urinary excretion of aquaporin-2 water channel protein in patients with congestive heart failur
作者:
卢武生1; 许顶立2; 孟素荣2; 鲁云敏1; 张俊松1; 陈虹1
1.解放军第一七五医院心血管科,福建漳州363000;2.第一军医大学南方医院心血管内科,广东广州510515
Author(s):
LUWu-sheng1; XUDing-li2; MENGSu-yun2; LUYun-min 1;  ZHANGJun-song1; CHEN Hong1
1.Department of Cardiovasology,175th Hospital of PLA,Zhangzhou,Fu jian363000,China;2. Department of Cardiovasology, Nan fang Hospital, First Military MedicalUniversity, Guang zhou, Guang dong510515,China
关键词:
水通道蛋白-2; 酶联免疫吸附测定; 心力衰竭; 充血性; 低钠血症
Keywords:
aquaporin-2; enzyme-linked immunosorbent assay; heart failure; congestive; hyponatremi
分类号:
R446.129;R541.61
DOI:
-
文献标识码:
A
摘要:
目的:探讨充血性心力衰竭(CHF)患者尿液水通道蛋白-2(aquaporin-2,AQP2)浓度的变化及其与低钠血症的关系。方法:应用双抗体夹心ELISA法检测CHF患者(364例)和健康对照者(82例)的尿液AQP2浓度,并测定血钠、左室射血分数(LVEF)等指标。结果:CHF患者比对照组尿AQP2的浓度明显增高(P<0.01),且CHF越重(NYHY等级越高、LVEF越小)及血钠越低,尿AQP2的浓度越高。结论:CHF患者水潴留及低钠血症越重,尿液AQP2排出越多。监测尿液AQP2浓度,为临床防治CHF及水钠失衡提供了新的检测指标和方法。
Abstract:
AIM:To study the changes of urinary concentration of aquaporin-2 (AQP2) water channel protein and the relation to hyponatremia.METHODS:Urinary AQP2 concentration of 82 healthy volunteers and 364 patients with congestive heart failure(CHF)was detected by double antibody sandwich ELISA, serum sodium and left ventricular ejection fraction (LVEF) were measured at the same time.RESULTS:The concentration of urinary AQP2 in CHF patients was higher than healthy volunteers,negative correlative with serum sodium concentration and LVEF.CONCLUSOIN:In patients with CHF, the more urinary AQP2 excrete, the more serious water retention and hyponatremia is. The detection of urinary AQP2 may reflect the severity of water retention and hyponatremia in body

参考文献/References

[1] Xu DL, Martin PY, Ohara M, etal. Upregulation of aquaporin-2water channel expression in chronic heart failure rat [J]. J Clin Invest, 1997,99(7):1500-1505.

[2]殷晓燕,许顶立,卢武生,等.心肌梗塞致心力衰竭大鼠模型不同时期尿液水通道蛋白-2的改变[J].中国病理生理杂志,2000,16(8):690-693.

[3]许顶立,任昊.充血性心力衰竭水储留的机制-Aquaporin-2水通道蛋白的作用[J].生理科学进展,2000,31(2):150-152.

[4]卢武生,许顶立,殷晓燕,等.尿液水通道蛋白-2双抗体夹心ELISA测定法的建立[J].第一军医大学学报, 2002, 22(6):486-489.

[5]卢武生,许顶立,孟素荣,等.ELISA法检测心力衰竭模型大鼠尿液水通道蛋白-2的变化及意义[J].第二军医大学南京军医学院学报,2002,24(3):150-152.

[6]Fushimi K,Uchida S,Hara Y,et al.Cloning and expression of apical membrane water channel of rat kidney collecting tubule [J]. Nature, 1993,361:549-552.

[7] Nielsen S, Terris J, Andersen D, et al. Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2water channel in collecting duct [J]. Proc Natl AcadSciUSA,1997,94:5450-5455.

[8] Martin PY, Abraham WT,Lieming X,et al.Selective v2-receptor vasopressin antagonism decreases urinary aquaporin-2 excretion in patients with chronic heart failure [J].J Am SocNephrol,1999,10:2165-2170.

[9]许顶立,殷晓燕,卢武生,等.尿液水通道蛋白-2的临床检测[J].肾脏病与透析肾移植杂志,2000,9(4):396-398

.[10]许顶立,殷晓燕,邓英姿,等.充血性心力衰竭患者尿液水通道蛋白-2的改变[J].中华内科杂志,2000,39(7):471-472

备注/Memo

备注/Memo:
收稿日期：2002-1-29.
更新日期/Last Update: 2003-05-01