我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

人参皂甙Rg1扩张兔基底动脉作用及其机制(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第4期
页码:
313-315
栏目:
实验研究
出版日期:
2003-07-01

文章信息/Info

Title:
Dilatory effects and its mechanism of ginsenosides Rg1 on basilar artery of rabbit
作者:
张志军; 江文; 万群
第四军医大学西京医院神经内科,陕西 西安 710032
Author(s):
ZHANG Zhi-jun;  JIANG Wen;  WAN Qun
Department of Neurology, Xijing Hospital, ForthMilitary Medical University, Xi'an, shaanxi 710032 , China
关键词:
人参皂甙Rg1; 动脉; 内皮细胞
Keywords:
ginsenosides Rg1;  artery;  endothelium
分类号:
R285.5
DOI:
-
文献标识码:
A
摘要:
目的:观察人参皂甙Rg1(G-Rg1)对基底动脉条的扩张作用,并探讨其作用机制。方法:采用离体血管条灌流实验法,观察G-Rg1对去甲肾上腺素(NA)、CaCl2、KCl反应的影响,以及去除内皮细胞后,G-Rg1扩血管作用的变化。结果:0.1mmol·L-1及0.01mmol·L-1G-Rg1分别使NA和CaCl2量效曲线明显右移,最大反应压低,非竞争性拮抗参数pD2'分别为3.64和4.66。G-Rg1对NA依内Ca2+性收缩和依外Ca2+性收缩均具有显著的抑制作用。去除内皮可明显减弱G-Rg1扩张KCl诱导的收缩血管作用。结论:G-Rg1既可通过抑制内Ca2+释放,也可抑制Ca2+通过电压依赖性Ca2+通道的内流,舒张脑基底动脉,其舒张作用有内皮依赖性。
Abstract:
AIM: To study the dilatory effects and mechanism of ginsenosides Rg1 (G-Rg1) on basilar artery of rabbit. METHODS: Organ-bath was used to observe the contractive response of arterial strip to noradrenaline (NA), CaCl2, KCl, and denude dendothelium. RESULTS: G-Rg1 caused right move of the concentration-response curves of NA in Krebs solution and CaCl2 in Ca2+-free Krebs containing K+, and decreased the maximum responses. It both reduced the contractive response of NA dependent on extracellular Ca2+ inflow and intracellular Ca2+ release. Denuded endothelium remarkably decreased the dilatory effect of G-Rg1 on arterial strip precontracted by KCl. CONCLUSION: G-Rg1 dilated basilar artery through inhibiting extracellular Ca2+ inflow and intracellular Ca2+ release of arterial smooth muscle cells.This effect was in endothelium dependent manner.

参考文献/References

[1] 李永杰, 于振香, 徐茂凤, 等. 人参二醇组皂甙对实验犬心肌缺血再灌注损伤保护作用的研究 [J] . 中国老年学杂志, 1998, 18(12):369-371.

[2] 李冬梅, 许逸, 傅万玉, 等. 人参皂甙Rg1对脑缺血大鼠软脑膜微循环的影响 [J] . 微循环学杂志, 1999, 9(1):8-11.

[3] Broekaert A, Godfriend T. A comparison of the inhibitory effect of cinnarizine and papaverine on the noradrenaline and calcium-evoked contraction of isolated rabbit aorta and mesenteric arteries [J] . Eur J Pharmacol, 1979, 53:281-284.

[4] 余丽梅, 黄燮南, 孙安盛. 普鲁托品对家兔主动脉扩血管作用的机制 [J] . 中国药理学与毒理学杂志, 2000, 14(1):21-25.

[5] Karaki H, Ozaki H, Hor M. Calcium movements, distribution, and functions in smooth muscle [J] . Pharm Rev, 1997, 49(2):157-230.

备注/Memo

备注/Memo:
收稿日期：2002-09-02.
更新日期/Last Update: 2003-07-01