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实验性血压变化对基础痛阈的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第5期
页码:
400-403
栏目:
实验研究
出版日期:
2003-09-01

文章信息/Info

Title:
Effects of experimental changes in blood pressure on basic pain threshold
作者:
陈亚宁1; 焦凯2; 高喜玲2; 刘晓宇2; 姬秋和1; 陈军3
第四军医大学: 1.西京医院内分泌科, 2.唐都医院内分泌科,3.全军神经科学研究所疼痛研究中心, 陕西 西安 710032
Author(s):
CHEN Ya-ning1;  JIAO Kai2;  GAO Xi-ling2;  LIU Xiao-yu2;  JI Qiu-he1;  CHEN Jun3
1.Department of Endocrinology in Xijing Hospital, 2.Department of Endocrinology in Tangdou Hospital, 3.Research Center of Pain in the Neuroscientific Institute of the Whole Army, Fourth Military Medical University, Xi’an, Shaanxi 710032, China
关键词:
血压; 痛阈; 热刺激缩足反应潜伏期; 机械刺激缩足反应潜伏期
Keywords:
blood pressure;  pain threshold;  paw withdrawal thermal latency;  paw withdrawal mechanical threshold
分类号:
Q463;Q432
DOI:
-
文献标识码:
A
摘要:
目的:观察左侧肾动脉结扎大鼠血压变化对热痛阈和机械痛阈影响的时程。方法: 将16只动物分为3组: 假手术组、肾动脉结扎组和肾动脉结扎+肌注利血平组, 每天在一定时间检测动脉收缩压(BP)、热刺激缩足反应潜伏期(PWTL) 和机械刺激缩足反应阈值(PWMT), 并作定量分析。结果: ①假手术组BP, PWTL 和PWMT均未发生明显变化(P>0.05)。②肾动脉结扎组大鼠血压在术后第1 天开始升高, 第3 天达峰值, 并维持在高血压水平(112±6 vs 160±8mm Hg), 平行观察显示PWTL 和PWMT 均随动脉收缩压升高而降低, 提示发生了热和机械痛敏现象。③利血平降压治疗后动脉收缩压虽然降至正常范围, 但热痛敏和机械痛敏却未被翻转。结论: 持续实验性高血压可能对伤害性反射的神经通路具有不可逆的调节作用。
Abstract:
AIM: To study the effect of the experimental changes in blood pressure on heat and mechanical pain sensitivity in the rats receiving ligation of the left renal artery (RA). METHODS: 16 rats were randomly divided in to three groups, ①sham group, ②RA-ligation group , ③RA-ligation + reserpine group. We measured blood pressure, paw withdrawal thermal latency (PWTL) and paw withdrawal mechanical threshold (PWMT) at set time everyday after operation. RESULTS: Blood pressure of RA-ligation group started to increase from the first day of post operation, and reached to the peak on the third day. From then on it maintained hypertensive status (112±6 mm Hg vs 160±8 mm Hg). At the same time PWTL and PWMT decreased with the increase of blood pressure. Antihypertensive therapy by reserpine couldn’t reverse heat and mechanic hypersensitivity. Blood pressure, PWTL and PWMT in sham group aren’t different from the baseline significiantly (P<0.05). CONCLUSION: Experimental hyperte sion have irreversible effect on nociceptive nervous pathway.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2003-01-14.
更新日期/Last Update: 2003-09-01