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氯吡格雷对不稳定型心绞痛患者血小板功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第5期
页码:
425-427
栏目:
临床研究
出版日期:
2003-09-01

文章信息/Info

Title:
Effect of clopidogrel on platelet function in patients with unstable angina pectoris
作者:
朱梅; 贾国良
第四军医大学西京医院心内科, 陕西 西安 710032
Author(s):
ZHU Mei;  JIA Guo-liang
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, China
关键词:
氯吡格雷; 不稳定型心绞痛; GMP2140; 血小板聚集率
Keywords:
clopidogrel;  unstable angina pectoris;  GMP2140;  platelet aggregaion
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:观察氯吡格雷对不稳定型心绞痛(UAP)患者血小板功能的影响, 探讨其临床应用价值。方法:UAP患者85例, 随机分为氯吡格雷负荷剂量组(n=30) , 氯吡格雷常规剂量组(n=30)及噻氯匹定治疗组(n=25)。所有患者在给予阿司匹林300 mg?d 的基础上, 氯吡格雷负荷剂量组1次性给予氯吡格雷(波立维) 300mg, 氯吡格雷常规剂量组给予波立维75 mg?d , 噻氯匹定组给予噻氯匹定(抵克力得) 250 mg?d, 观察3组患者治疗前, 氯吡格雷负荷剂量组给药2h 后, 氯吡格雷常规剂量组及噻氯匹定组给药3d 后患者血浆GMP2140 含量及血小板最大聚集率(M PAR) 的变化。结果: 各组患者治疗后血浆GM P2140 含量及MPAR 较治疗前显著降低(P<0.01) , 组间血浆GMP2140含量及MPAR无显著性差异(P>0.05)。结论: 氯吡格雷起效迅速, 首剂负荷剂量300mg 服药后2 h 即可有效抑制血小板激活, 可达到服用常规剂量氯吡格雷或噻氯匹定连续3 d 抑制血小板激活的效果。
Abstract:
AIM: To investigate the effect of clopidogrel on platelet activation in patients with unstable angina pectoris (UAP), and to discuss its clinical value. METHODS: 85 UAP patients were randomly divided into three groups: clopidogrel loading dose group (n=30), clopidogrel routine dose group (n=30) and ticlopidine group (n=25). All the patients were given aspirin 300m g?d as the base treatment, then the colpidogrel loading group patients were given polivex bolus 300mg; the clop idogrel routine dose group patients were given polivex 75mg?d on 3 successive days and the ticlopidine group patients were given ticlid 250 mg?d on 3 successive days. 2 hours after the first drug in take of clopidogrel loading dose group , and 3 days after drug intake of clopidogrel routine dose group and ticlopidine group. Venous blood was sampled for the determination of markers of plasma GMP2140 and maxplatelet aggregation rate (MPAR) induced by ADP pretreatment. RESULTS: At post-treatment plasma GMP2140 antigen and MPAR of all the three groups were lower than pre-treatment (P<0.01), but there was no significant difference between the three groups (P>0.05). CONCLUSION: Clopidogrel takes effect quickly. Loading dose 300m g can inhibit platelet activation in 2 hours, and achieve the similar effect gained by 3 successive days’administration of routine dose of clopidogrel or ticlopidine.

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备注/Memo

备注/Memo:
收稿日期：2002-11-28.
更新日期/Last Update: 2003-09-01