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高血压病对心肾的损害程度及其相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第5期
页码:
434-436
栏目:
临床研究
出版日期:
2003-09-01

文章信息/Info

Title:
The seriousness and correlation in impaired heart and kidney in hypertension patients
作者:
程志坚1; 邓学东2; 沈延政2; 黄敏2; 裘建明3; 何巧平1; 严禹2; 孙勤2
南京医科大学附属苏州第四人民医院: 1.心内科, 2. 苏州超声医学研究室, 3. 同位素室, 江苏 苏州 215001
Author(s):
CHENG Zhi-jian1;  DENG Xue-dong2;  SHEN Yan-zheng2;  HUANG Min2;  QIU Jian-ming3;  HE Qiao-ping1;  YAN Yu2;  SUN Qin2
Department of Cardiology, Fourth Affiliated Hospital, Nanjing Medical University, Suzhou, Jiangsu 215001, China
关键词:
高血压; 心肾损害; 相关性
Keywords:
hypertension;  impaired heart and kidney;  correlation
分类号:
R541.3
DOI:
-
文献标识码:
A
摘要:
目的:探讨高血压病心肾损害严重程度及其相关性。方法: 对85 例高血压病患者和20例健康者超声心动图,肾功能, 肾动脉血流动力学, 血尿B2微球蛋白(B-MG), 体重指数(BMI), 等结果进行对比。结果:①高血压? 期心脏以向心性肥厚为主, ? 期以离心性肥厚为主, 室间隔增厚均大于左室后壁, 左室质量指数(LVMI)进行性增大。②高血压病?2?期肾功能进行性受损, 血液尿素氮(BUN)、肌酐(Cr)增高, 肌酐清除率(Ccr)降低, 血尿B2-MG 增加。③肾动脉最大血流速度(Vmax), 血管阻力指数(RI)增高伴随肾功能恶化。④ 高血压病晚期BMI减少. ⑤回归分析显示:LVMI?K(K 值: 男134, 女110)与Ccr 呈负相关, Ccr与RI呈负相关, 但LVM I?K 与RI相关性不显著。结论:高血压病对心脏, 肾脏同时产生损害, 损害程度具有相关性。
Abstract:
AIM: To study the seriousness and correlation in impaired heart and kidney in hypertensive patients. METHODS: The echocardiographies, renal arterial hemodynamics, renal function, B-microglobulin (B-MG) in blood and urine, body mass index (BMI) of 85 hypertensive patient s and the renal arterial hemodynamics of 20 healthy men were analysed. RESULTS: ①Most of the patients with ? phase hypertension suffered concen tric hypertrophy. While most of patients with ? phase hypertension had eccentric hypertrophy. The septum was thicker than the posterior wall in both the ? and ? phase hypertensive patients. Left ventricular mass index(LVMI) increased progressively in ?, ? and ? phase hypertensive patients. ②Renal function was damaged progressively, blood urea nitrogen (BUN) and creatinine clearance (Ccr) declined, and B-MG in blood and urine rose in all the above hypertensive patients. ③V max and vascular resistance index (RI) in renal artieral hemodynamics increased progressly with the worsening of renal function. ④Body mass index (BMI) decreased in the late hypertensive patients. ⑤Linear regression analysis showed that LVM I?K (K value: 134 in men, 110 in women) was negatively correlated with Ccr, which was negatively correlated with RI, but LVM I?K did not correlate significantly with RI. CONCLUSION: Hypertension brought about impaired heart and kidney at the same time. There was a correlation between the impaired heart and kidney

参考文献/References

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[5] Porush JG. Hypertension and chronic renal failure: the use of ACE inhibitors [J] . Am J Kidney Dis, 1998, 31:177-184.

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备注/Memo

备注/Memo:
收稿日期：2002-08-07.
更新日期/Last Update: 2003-09-01