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内皮素-1与肺缺血/再灌注损伤的实验研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第6期
页码:
508-510
栏目:
实验研究
出版日期:
2003-11-01

文章信息/Info

Title:
Experiment studies on the effect of endothelin-1 on ischemia/reperfusion lung in rabbit model
作者:
曹华1; 廖崇先1; 陈道中1; 黄雄飞2; 陈敏3
1.福建省胸心外科研究所, 福建医科大学附属协和医院心外科, 福建 福州 350001; 2.福建医科大学病理解剖学教研室;3.第四军医大学西京医院心外科
Author(s):
CAO Hua1;  LIAO Chong-xian1;  CHEN Dao-zhong1;  HUANG Xiong-fei2;  CHEN Min3
1.Department of Cardiovascular Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, China
关键词:
内皮素-1; 缺血/再灌注; 损伤; 肺
Keywords:
endothelin-1;  ischemia/reperfusion;  injury;  lung
分类号:
R543.2
DOI:
-
文献标识码:
A
摘要:
目的:探讨内皮素-1 (ET-1) 在肺缺血/再灌注(I/R) 损伤中的作用。方法: 健康新西兰大白兔30只随机分成3组(每组10只): 假手术组(?组)、I/R + 生理盐水(?组)和I/R + ET-1 抗体组(?组)。观察肺再灌注0,60, 120, 240min各时间点肺动脉压(PA)、动脉氧分压(PaO2)和血浆ET-1的变化。实验结束时, 检测支气管肺泡灌洗液(BALF)中ET-1和肺组织丙二醛(MDA) 的含量和肺组织光镜的变化。结果: ? 组血浆和BALF 的ET-1水平、肺组织MDA 含量和PA 升高, PaO2降低。?组PA和PaO2没有明显变化, 血浆和BALF的ET-1水平、肺组织MDA含量的升高得到抑制。结论: ET-1 参与肺缺血?再灌注损伤, 能改善PA 和PaO2。
Abstract:
AIM: To investigate the effect of endothelin-1 on lung ischemia/reperfusion (I/R) injury in rabbits. METHODS: Thiry New Zealand rabbits were divided into three groups: group ?, sham-operated; group ?, I/R + physiologic saline and group ?, I/R + endothelin-1 antibody. Pulmonary artery pressure (PA) , arterial oxygen tension (PaO2) and plasm a endothelin-1 (ET-1) were measured at different time points. The concent rations of ET-1 in bronchio-alveolar lavage fluid (BALF) and malondialdehyde (MDA) in the lungs were analysed. Mean while, the histopathologicall alterations in the lungs were observed. RESULTS: The marked increase of PA, ET-1, MDA and the decrease of PaO2 were observed after lung ischemia/reperfusion, whereas in the ET-1 antibody PA were significantly devreased and PaO2 was reduced. CONCLUSION: ET-1 might participate in the injury due to the lung ischemia/reperfusion and improve PA and PaO2.

参考文献/References

[1] Yanagisawa M, Kurihara H, Kimuras E, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells [J] . Nature, 1988, 332:411-415.

[2] Yoshizumi M, Kurihara H, Morita T, et al. Interleukin-1 increases the production of endothelin-1 by cultured endothelial cells [J] . Biochem Biophys Res Commun, 1990, 166:324-329.

[3] tsao PS, Lefer AM. Time course and methanism of endothelial dysfunction in isolated ischemic-and-hypoxic-perfused rat hearts [J] . Am J Physiol, 1990, 259:H1660-H1666.

[4] Yang XL, Zhou WB. Effect of endothelin on the lung and its progress in study [review] [J] . Foreign Med Sci Respir Dis Fas, 1998, 18:104-107.

[5] 汤健, 唐朝枢, 杨军, 等. 内皮素 [M] . 北京: 北京医科大学中国协和医科大学联合出版社, 1994. 137-164.

[6] Nucci G, Thomas R. Pressor effects of circulating endothelin are limited by its removal in the pulmonary [J] . Proc Natl Acad Sci USA, 1988, 85:9797-9801.

备注/Memo

备注/Memo:
收稿日期：2002-04-23.
更新日期/Last Update: 2003-11-01