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|本期目录/Table of Contents|

阿司匹林在心血管病患者中的抵抗现象(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第6期
页码:
534-536
栏目:
临床研究
出版日期:
2003-11-01

文章信息/Info

Title:
Prevalence of aspirin resistance in patients with cardiovascular disease
作者:
涂昭辉1;  吴宣树2
解放军425医院: 1.心内科, 2.医务科, 海南 三亚 572008
Author(s):
TU Zhao-hui1;  WU Xuan-shu2
425 Hospital of PLA, Sanya, Hainan 572008, China
关键词:
冠状动脉疾病; 阿司匹林; 抵抗; 流行病学
Keywords:
cardiovascular disease;  aspirin;  resistance;  prevalence
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:调查冠心病患者发生阿司匹林抵抗(AR)的发生率和流行病学特征, 并探讨其相关因素。方法: 病情稳定的冠心病患者209例, 每日服用阿司匹林100mg, 连服7d, 服用最后一剂后24h内抽取空腹静脉血, 分别用二磷酸腺苷(ADP)、花生四烯酸(AA)诱导血小板凝集试验(PAgT) , 检测血小板聚集率。结果: 患者中AR发生率为3.8%, 阿司匹林半敏感(ASR) 者占25.8%, 且AR 或ASR 患者中的女性比率较阿司匹林敏感者(AS)高(P<0.05), 而AS者中吸烟者较AR或ASR 者多(P<0.01)。结论: 阿司匹林用于抗血小板治疗及预防动脉硬化事件的冠心病患者可产生AR, 预测AR及抗血栓治疗个体化, 将有利于抗血栓治疗。
Abstract:
AIM: To invastigate the prevalence of aspirin resistance (AR) in the patients with cardiovascular disease and further clarify the clinical predictors. METHODS: The patients with stable cardiovascular diseases who were receiving 100 mg/d aily of aspirin for 7 days, but no other antiplatelet agent. Their blood samples were analyzed for AR by platelet aggregation test (pAgT) using adenosine diphosphate (ADP) and arachidonic acid (AA). RESULTS: 3.83% of the patients showed AR and 25.8% of them showed aspirin semiresponders (ASR). Patients who were either AR or ASR were more likely to be women (P<0.05) and less likely to be smokers (P<0.01) compared with aspirin-sensitive patients. CONCLUSION: The finding of AR could be of particular importance, given the large mumber of patients relying on this medications for antiplatelet protection. Now that there are so many safe alternative anti-platelet agents available for longterm administration, to identify patient with aspirin resistance appears to be of great help in trating patients with cardiovascular disease.

参考文献/References

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[5] Grotemeyer KH, Scharafinski HW, Husstedt IW. Two-year follow-up of aspirin responder and aspirin nonresponder. Apilot-study including 180 post-stroke patients [J] . Thromb Res, 1993, 71:397-403.

[6] Leon MB, Baim DS, Popma JJ, et al. A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. Stent Anticoagulation Restenosis Study Investigators [J] . N Engl J Med, 1998, 339:1665-1671.

[7] Alexander JH, Harrington RA, Tuttle RH, et al. Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes. PURSUIT Investigators. Platelet ?/? a in Unstable angina: Receptor Suppression Using Integrilin Therapy [J] . Am J Cardiol, 1999, 83:1147-1151.

[8] Taylor DW, Bamett HJ, Haynes RB, et al. Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomised controlled trial. ASA and Carotid Endarterectomy (ACE) Trial Collaborators [J] . Lancet, 1999, 353:2179-2184.

备注/Memo

备注/Memo:
收稿日期：2002-11-07.
更新日期/Last Update: 2003-11-01