我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

内源性保护蛋白与心肌缺血预处理的延迟效应(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第6期
页码:
563-566,569
栏目:
综述
出版日期:
2003-11-01

文章信息/Info

Title:
-
作者:
余洋 综述; 黄德嘉 审校
四川大学华西医院心血管内科, 四川 成都 610041
Author(s):
-
关键词:
内源性;  蛋白;  缺血预处理;  延迟
Keywords:
-
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
缺血预处理(IP)对长时间缺血的心肌具有明显的保护作用。IP 的延迟效应(DP) 比早期效应更有意义, 它持续的时间较长、作用更广泛。内源性保护蛋白在DP 中扮演着关键的角色。那么, 这些内源性蛋白究竟有哪些? 它们的作用机制及其临床意义又怎样? 本文作者就DP 中内源性保护蛋白的研究进展做一综述。
Abstract:
-

参考文献/References

[1] Rizvi A, Tang XL, Qiu Y, et al. Increased protein synthesis is necessary for the development of late preconditioning against myocardial stunning [J] . Am J Physiol, 1999, 277(3Pt2):874-884.

[2] Wang Y, Guo Y, Zhang SX, et al. Ischemic preconditioning up regulates inducible nitric oxide synthase in cardiac myocyte [J] . J Mol Cell Cardiol, 2002, 34(1):5-15.

[3] Guo Y, Jones WK, Xuan YT, et al. The late phase of ischemic preconditioning is abrogated by targeted disruption of inducible No synthase gene [J] . Proc Natl Acad Sci USA, 1999, 96(20):11507-11512.

[4] Kim SJ, Kim YK, Takagi G, et al. Enhanced iNOS function in myocytes one day after brief ischemic episode [J] . Am J Physiol Heart Circ Physiol, 2002, 282(2):423-428.

[5] Xuan YT, Tang XL, Qiu Y, et al. Biphasic response of cardiac No synthase isoforms to ischemic preconditioning in couscious rabbits [J] . Am J Physiol Heart Circ Physiol, 2000, 279(5):2360-2371.

[6] Zhao T, Xi L, Chelliah J, et al. Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A (1) receptors: evidence from gene-knock out mice [J] . Circulation, 2000, 102(8):902-907.

[7] 李伟杰, 贾国良, 郭文怡. 一氧化氮参与了缺血预处理后5’2 苷酸酶的延迟升高 [J] . 心脏杂志, 2002, 14(3):189-194.

[8] Shinmura K, Tang XL, Wang Y, et al. Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits [J] . Proc Natl Acad Sci USA, 2000, 97(18):10197-10202.

[9] Guo Y, Bao W, Wu WJ, et al. Evidence for an essential role of cyclooxygenase-2 as a mediator of the late phase of ischemic preconditioning in mice [J] . Basic Res Cardiol, 2000, 95(6):479-484.

[10] 臧益民, 臧伟进, 朱妙章. 心脏与内分泌 [J] . 心脏杂志, 2001, 13(6):557.

[11] Song QJ, Xiao J, Deng HW, et al. Role of calcitonin gene-related peptide in prostaglandins-mediated ischemic preconditioning in guinea pig hearts [J] . Acta Pharmacol Sin, 2001, 22(1):3-9.

[12] Zhou FW, Li YJ, Lu R, et al. Protection of calcitonin gene-related peptide-mediated preconditioning against coronary endothelial dysfunction induced by reperfusion in the isolated rat heart [J] . Life Sci, 1999, 64(13):1091-1097.

[13] Zhou FW, Li YJ, Deng HW. Eealy and delayed protection by capsaicin against reperfusion injury in rat hearts [J] . 中国药理学报, 1999, 20(10):912-916.

[14] Ebrahim Z, Yellon DM, Baxter GF. Bradykinin elicits“second window”myocardial protection in rat heart through an NO-dependent mechanism [J] . Am J Physiol Heart Circ Phy siol, 2001, 281(3):1458-1464.

[15] 汝磊生, 李飞, 贾国良, 等. 缓激肽对缺血-再灌注兔心肌能量代谢的延迟作用 [J] . 第四军医大学学报, 2001, 22(21):1943-1945.

[16] Kositprapa C, Ockaili RA, Kukreja RC. Bradykin in B-receptors is involved in the late phase of preconditioning in rabbit heart [J] . J Mol Cell Cardio, 2001, 33(7):1355-1362.

[17] Jaberansari MT, Baxter GF, Muller CA, et al. Angiotensin-converting enzyme inhibition enhances a subthreshold stimulus to elicit delayed preconditioning in pig myocardium [J] . J Am Coll Cardiol, 2001, 37(7):1996-2001.

[18] Yamashita N, Hoshida S, Otsu K, et al. The involvement of cytokines in the second window of ischaemic preconditioning [J] . Br J Pharmacal, 131(2000):415-422.

[19] Hoshida S, Yamashita N, Otsu K, et al. The importance of manganese superoxide dismutase in delayed preconditioning: involvement of reactive oxygen species and cytokines [J] . Cardiovasc Res, 2002, 55(3):495-505.

[20] Kang YJ, Li GQ, Sa JT. Metallothinein involvement in the delayed protection after ischemic or anoxic preconditioning in myocardium of cultured cardiomyocytes [J] . Ajp-heart and circulation physiology, 1999, 276(3):993-997.

[21] Wang GW, Zhou Z, Klein JB, et al. Inhibition of hypoxia?reoxy-genation-induced apoptosis in metallothioein-over expressing cardiomyocytes [J] . Am J Physiol Heart Circ Physiol, 2001, 280(5):2292-2299.

[22] 金慧英, 李法卿. 金属硫蛋白在培养乳鼠心肌细胞缺氧预处理中的作用 [J] . 中国病理生理杂志, 2000, 16(4):316-318.

备注/Memo

备注/Memo:
收稿日期：2002-12-05.
更新日期/Last Update: 2003-11-01