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|本期目录/Table of Contents|

辛伐他汀在不稳定型心绞痛患者早期应用的疗效(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第2期
页码:
140-142
栏目:
临床研究
出版日期:
2004-03-01

文章信息/Info

Title:
Efficacy and safety of Simvastatin in early-period of unstable angina pectoris
作者:
高智耀1; 雷兆军2; 李亚军1; 王晓明3
1.延安大学医学院第二附属医院心内科,陕西 绥德 718000; 2.核工业咸阳215医院,陕西 咸阳 712000; 3.第四军医大学西京医院老年病科, 陕西 西安710032
Author(s):
AO Zhi-yao1; LEI Zhao-jun2; LI Ya-jun1; WANG Xiao-ming3
1.Departmentofcardiology,SecondAffillatedHospitalofYananUniversity,Suide,Shaanxi 718000,China
关键词:
心绞痛; 不稳定型; 血脂; 辛伐他汀
Keywords:
anginapectoris;  unstable;  serum lipid;  Simvastatin
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:探讨辛伐他汀对不稳定型心绞痛(UAP)发生早期(24～96h)开始应用的疗效及安全性。方法:临床确诊为UAP患者89例,随机分为对照组(常规治疗,45例),辛伐他汀组(常规治疗外,加服辛伐他汀,44例),于治疗前、治疗后3、6和12个月时分别测肝功、肾功、肌酶谱、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、一氧化氮(NO)、C-反应蛋白(CRP)、高密度脂蛋白胆固醇(HDL-C),24hHolter检测心肌缺血总负荷(TIB)和心血管缺血相关事件。结果:辛伐他汀6个月后能有效地降低UAP患者血清TC、LDL-C、CRP,升高NO,HLD-C,与对照组比较有显著性差异(P<0.01);两组患者每周心绞痛发作次数及TIB均有减少,但辛伐他汀组更明显(P<0.05);其缺血相关事件亦有显著性差异(P<0.01)。辛伐他汀组中有4例轻度转氨酶升高,2例出现腹胀。结论:UAP发病早期应用辛伐他汀能安全、有效地降低血脂和CRP,升高NO,显著减少心血管缺血相关事件发生率。
Abstract:
AIM:To explore the effect and safety of Simvastatin on patients with unstable angina pectoris (UAP) in early-period (24～96h). METHODS: Eighty-nine patients with UAP were randomly divided into control group (with conventional drugs,n=45) and Simvastatin group (with conventional drugs and Simvastatin, n=44). It was tested myocardial enzymy, liver function, kidney function, total cholesterol(TC), Low-density lipoprotein cholesterol (LDL-C), Nitric oxide (NO), C-reactive protein(CRP), high-density lipoprotein cholesterol (HDL-C) and under went total ischemic burden(TIB) monitoring from 24 hour ambulator yelectrcardigram recording and observation of ischemiare lated events before and 3、6 and 12 months after therapy. RESULTS: The serum TC, LDL-C, CRP in Simvastatin group were obviously decrease than the control group after 6,12 months of therapy (P<0.01), yetthe serum NO,HDL-C were markly increased after 12-month treatment (P<0.05). After treatment, frequency of anginapectoris and TIB of both groups were decreased, but the Simvastatin group was further (P<0.05), so as of acute myocardial infarction (P<0.05). Four patients had slighte lavation of ALT and 2 had abdominal distensionin Simvastation group. CONCLUSION: Simvastatin is a effect and safety drug to take anti-myocardial ischemic and lipid-lowering, also can reduce the ischemia related events

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备注/Memo

备注/Memo:
收稿日期：2003-3-31
更新日期/Last Update: 2004-03-01