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左旋卡尼汀对心力衰竭患者血清游离脂肪酸浓度的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第3期
页码:
226-227,231
栏目:
临床研究
出版日期:
2004-05-01

文章信息/Info

Title:
Effects of L-carnitine on the level of serum free fatty acid in patients with congestive heart failure
作者:
周琴玲1;  殷仁富2;  任雨笙2;  李艳平1
1.武警甘肃总队医院内三科，甘肃 兰州 730050; 2.第二军医大学附属长征医院心内科，上海 200003
Author(s):
HOU Cui-Zing; YIN Ren-fu; REN Yu-sheng; Ll Yan-ping
Department of Cardiovasology，Changzheng Hospital，Second Miltary Medical University Shanghai 200003,China)
关键词:
左旋卡尼汀; 心力衰竭; 充血性; 脂肪酸; 游离
Keywords:
L-carnitine; Congestive heart failure; Free fatty acid
分类号:
R541-6
DOI:
-
文献标识码:
A
摘要:
目的:探讨左旋卡尼汀(L-CN)治疗充血性心力衰竭(CHF)的临床疗效及对血清游离脂肪酸(FFA)浓度的影响。方法:CHF患者50例，分为L-CN组(25例)和对照组〔25例)。对照组采用常规药物治疗，L-CN组常规药物加L-CN治疗，采用醉比色法测定治疗前、后血清FFA浓度，并观察心功能改变情况。结果:CHF患者治疗后血清中FFA浓度较治疗前明显下降(P<0.05 或P<0.01 )，且L-CN组FFA浓度在治疗后显著低于对照组(P<0.0 5);治疗后两组心功能较治疗前明显改善，L-CN组心功能改善程度较对照组更明显，L-CN组治疗显效率及总有效率均商于对照组(P<0.05 ),结论:L-CN治疗不但能改善心功能，而且能降低血清FFA水平。
Abstract:
AIM:To investigate the effects of L-Carnitine (L-CN)on the level of free fatty acid(FFA)and cardiac function in patients with congestive heart failure (CHF). METHODS:Fifty patients with CHF were divided into control group and L-CN group (25 patients for each group).The control group received routine medication:digitalis，diuretics，vasodilator，ACEI and beta blocker，while the L-CN group were given intravenously L-carnitine 3.0 g for 10 days.The blood samples for assay of serum levels of FFA were taken before and after the treatment. In addition，changes in cardiac function of the patients were observed. RESULTS:The levels of FFA significantly decreased after L-CN treatment compared with those of the control group and before the treatment (P<0. 05 or 0. 01)，and cardiac function of CHF patients after the L-CN treatment were improved compared with that of the control group(P <0.05 ).CONCLUSION: L-CN may improve cardiac function in patients with CHF and decrease the level of FFA.

参考文献/References

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[3] Helton E, Darragh R, Francis P, et al. Metabolic aspects of myocardiald is ease and role of L-carnitine in the treatment of children cardiomyopathy[J].Pediartics,2000,105(5):1260-1270.

[4] Northammar A, Malmberg K. Heart failure and glucose abnorma lies, an increasing combination with poor functional capacity and outcome[J].Eur H eart J,2000,21(16),1293一1298.

[5] Razeghi P, Young ME, Alcom JL, et al. Metabolic gent expression in fetal and failing human heart[J].Circulation,2001,104(24),2923-2927.

[6] Carvani M, Reda E, Arrigoni-Martelli E. Ragulation by carnitine of myocardial fatty acid and carbohydrate metabolism under normal and pathological conditions[J].Basic Res Cardiol, 2000, 95(1),75-83.

[7] 王咏梅，殷仁富，吴宗贵，等.慢性充血性心力衰竭患者血浆游离肉毒碱浓度降低的临床意义[J].国际心血管杂志，2002,4(1), 39-41.

[8] Rizxos l. Three-year survival of patient with heart failure caused by dilated cardiomyopathy and L-carnitine administration[J].Am Heart J,2000,139(2 pt 3).S121一S123.

备注/Memo

备注/Memo:
收稿日期：2003-7-28
更新日期/Last Update: 2004-05-01